, Volume 156, Issue 1, pp 9–11 | Cite as

Intestinal candidiasis. A clinical report and comments about this opportunistic pathology

  • D. Ruiz-Sánchez
  • L. Calderón-Romero
  • J. T. Sánchez-Vega
  • J. Tay


An eight-years-old girl, who presented with recurrent upper respiratory tract infections, was treated with broad-spectrum antibiotics. Afterward she presented with intestinal candidiasis. The isolated species was identified as Candida albicans by differential tests. Treatment given was with 500,000 IU of oral nystatin every 8 hours for 10 days and intestinal normal microbiota restoratives. Evolution has been satisfactory, although concomitantly type A hepatitis developed. Rest and a soft diet were recommended. The child is now perfectly healthy with normal liver function tests. Conclusion: Prolonged treatments with broad-spectrum antibiotics destroyed the indigenous intestinal microbiota, which provoked intestinal C. Albicans proliferation and adversely affected the immunological system of the patient, thus facilitating the establishment of a viral infection.

broad-spectrum antibiotics Candida albicans indigenous intestinal microbiota intestinal candidiasis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kennedy MJ, Volz PA. Ecology of Candida albicans gut colonization: Inhibition of Candida adhesion, colonization and dissemination from the gastrointestinal tract by bacterial antagonism. Infect Immunity 1985; 49: 654–663.Google Scholar
  2. 2.
    de Repentigny L, Aumont F, Bernard K, Belhumeur P. Characterization of binding of Candida albicans to small intestinal mucin and its role in the adherence to mucosal epithelial cells. Infect Immunity 2000; 68: 3172–3179.CrossRefGoogle Scholar
  3. 3.
    Colina AR, Aumont F, Deslauriers N, Bellmineur P, de Repentigny L. Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase. Infect Immunity 1996; 64: 4514–4519.Google Scholar
  4. 4.
    Bond S, Stwart DL, Bendon CW. Invasive Candida enteritis in the new born. J Pediatr Sur 2000; 35: 1496–1498.CrossRefGoogle Scholar
  5. 5.
    Stachowitz S, Abeck D, Schmiath T, Ring J. Persistent annular erythema of infancy associated with intestinal Candida colonization. Clin Exp Derm 2000; 25: 404–405.CrossRefPubMedGoogle Scholar
  6. 6.
    Isenberg HD, Pisano MA, Carito SL, Berkman JI. Factors leading to overt monilial disease. Preliminary studies of the ecological relationship between Candida albicans and intestinal bacteria. Antibiot Chemother 1960; 6: 353–363.Google Scholar
  7. 7.
    Seelig MS. Mechanisms by which antibiotics increase the incidence and severity of candidiasis and alter the immunological defenses. Bacteriol Rev 1966; 30: 442–459.PubMedGoogle Scholar
  8. 8.
    Seelig MS. The role of antibiotics in the pathogenesis of Candida infections. Am J Med 1966; 40: 87–917.CrossRefGoogle Scholar
  9. 9.
    Wals TJ, González C, Klyman CA, Chanock SJ, Pizzo PA. Invasive fungal infections in children: Recent advances in diagnosis and treatment. Adv Pediatr Infect Dis 1996; 11: 180–290.Google Scholar
  10. 10.
    Fisher-Hoch S, Huatwagner L. Opportunistic candidiasis: An epidemic of the 80's. Clin Inf Dis 1995; 21: 897–904.Google Scholar
  11. 11.
    Bandarinarayanan G, Gowrisankar R, Muthulakshmi K. Esophageal candidiasis in non-immune suppressed patients in a semi-urban town, southern India. Mycopathologia 2000; 149: 1–4.CrossRefPubMedGoogle Scholar
  12. 12.
    Zimmerman LE. Fatal fungus infections complicating other diseases. Am J Clin Pthol 1995; 25: 46–65.Google Scholar
  13. 13.
    Alam SA, Tahir M, De MN. Candida as a cause of diarrohoea in children. Bangladesh Med Res Counc Bull 1977; 3: 32–36.PubMedGoogle Scholar
  14. 14.
    Wagner RD, Warner T, Pierson C, Roberts L, Farner J, Dohnalek M, Hilty M, Balish E. Variable biotherapeutic effects of Biffidobacterium spp. on orogastric and systemic candidiasis in immunodeficient mice. Rev Iberoam Micol 1998; 15: 265–270.Google Scholar
  15. 15.
    Wagner RD, Warner T, Roberts L, Farmer J, Dohnalek M, Hilty M, Balish E. Variable biotherapeutic effects of Lactobacillus acidophilus isolates on orogastric and systemic candidiasis in immunodeficient mice. Rev Iberoam Micol 1998; 15: 271–276.Google Scholar
  16. 16.
    Berg R, Bernasconi P, Fowler D, Gantreux M. Inhibition of Candida albicans translocation from the gastrointestinal tract of mice by oral administration of Sacharomyces boulardii. J Inf Dis 1993; 168: 1314–1318.Google Scholar
  17. 17.
    Hilton E, Isenberg HD, Alperstein P, France K, Borentein M. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis. Ann Intern Med 1992; 116: 353–357.PubMedGoogle Scholar
  18. 18.
    Symposium LACTEOL 2000 Nuevas Perspectivas Fundamentales y Clínicas sobre el uso Terapéutico del liofilizado del termolizado de Lactobacillus acidophilus boucardii cepa L.B. en el tratamiento del Síndrome Diarreico. Rev Enf Pediatr 2001; Vol. XIV, NÚmero especial.Google Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • D. Ruiz-Sánchez
    • 1
  • L. Calderón-Romero
    • 1
  • J. T. Sánchez-Vega
    • 1
    • 2
  • J. Tay
    • 1
  1. 1.Laboratory of Parasitology, Department of Microbiology and Parasitology, Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico
  2. 2.Familiar Medicine Unit No. 28 ``Gabriel Mancera''Mexican Institute of Social SecurityMexico CityMexico

Personalised recommendations