Journal of Bioenergetics and Biomembranes

, Volume 34, Issue 5, pp 327–332

Transport ATPases in Biological Systems and Relationship to Human Disease: A Brief Overview

  • Peter L. Pedersen

DOI: 10.1023/A:1021249701287

Cite this article as:
Pedersen, P.L. J Bioenerg Biomembr (2002) 34: 327. doi:10.1023/A:1021249701287


Interest in the field of transport ATPases has grown dramatically during the past 20 years and gained considerable visibility for several reasons. First, it was shown that most transport ATPases can be lumped into only a few categories designated simply as P, V, F, and ABC types, the latter consisting of a large superfamily. Second, it has been shown that many transport ATPases have a clear relevance to human disease. Third, the field of transport ATPases has become rather advanced in the study of the reaction mechanisms and structure–function relationships associated with several of these enzymes. Finally, the Nobel committee recently recognized major accomplishments in this field of research. Here, the author provides a brief discussion of transport ATPases that are present in biological systems and their relevance or possible relevance to human disease.

ATPase transport ATPase ion-motive ATPases P-type ATPase V-type ATPase F-type ATPase ATP synthase ABC transporters human disease 

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Peter L. Pedersen
    • 1
  1. 1.Department of Biological Chemistry, School of MedicineJohns Hopkins UniversityBaltimore

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