Cancer and Metastasis Reviews

, Volume 21, Issue 3–4, pp 257–264

Carotenoids in Cancer Chemoprevention

  • Hoyoku Nishino
  • Michiaki Murakoshi
  • Tsunehiro Ii
  • Manabu Takemura
  • Masashi Kuchide
  • Motohiro Kanazawa
  • Xiao Yang Mou
  • Saeri Wada
  • Mitsuharu Masuda
  • Yasuhito Ohsaka
  • Shingo Yogosawa
  • Yoshiko Satomi
  • Kenji Jinno
Article

Abstract

Various natural carotenoids, besides β-carotene, were proven to have anticarcinogenic activity, and some of them showed more potent activity than β-carotene. Thus, these carotenoids (α-carotene, lutein, zeaxanthin, lycopene, rbeta β-cryptoxanthin, fucoxanthin, astaxanthin, capsanthin, crocetin and phytoene), as well as β-carotene, may be useful for cancer prevention. In the case of phytoene, the concept of 'bio-chemoprevention', which means biotechnology-assisted method for cancer chemoprevention, may be applicable. In fact, establishment of mammalian cells producing phytoene was succeeded by the introduction of crtB gene, which encodes phytoene synthase, and these cells were proven to acquire the resistance against carcinogenesis. Antioxidative phytoene-containing animal foods may be classified as a novel type of functional food, which has the preventive activity against carcinogenesis, as well as the ability to reduce the accumulation of oxidative damages, which are hazardous for human health.

natural carotenoids multicarotenoids cancer chemoprevention bio-chemoprevention functional foods 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Hoyoku Nishino
    • 1
  • Michiaki Murakoshi
    • 1
    • 2
  • Tsunehiro Ii
    • 1
  • Manabu Takemura
    • 1
  • Masashi Kuchide
    • 1
  • Motohiro Kanazawa
    • 3
  • Xiao Yang Mou
    • 1
  • Saeri Wada
    • 1
  • Mitsuharu Masuda
    • 1
  • Yasuhito Ohsaka
    • 1
  • Shingo Yogosawa
    • 1
  • Yoshiko Satomi
    • 1
  • Kenji Jinno
    • 4
  1. 1.Department of BiochemistryKyoto Prefectural University of MedicineKawaramachi-Hirokoji, Kamigyoku, Kyoto
  2. 2.Research & Development HeadquartersLion CorporationOdawara, Kanagawa
  3. 3.Department of UrologyKyoto Prefectural University of MedicineKawaramachi-Hirokoji, Kamigyoku, Kyoto
  4. 4.Internal MedicineShikoku Cancer CenterMatsuyama, EhimeJapan

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