Can Analysis of Transmitral Flow-Velocity Contours Differentiate Between Alternative Diastolic Pressure–Volume Relations?

  • Brian S. Oommen
  • Mustafa Karamanoglu
  • Sándor J. Kovács
Article

Abstract

Several expressions have been considered for the diastolic pressure–volume (PV) relation whose mechanical analogue is the force–length relation. How alternative PV relations modify transmitral flow (Doppler E-wave) velocity contours has not been explored. The linear force–length term of a previously validated lumped parameter transmitral flow model was replaced by a logarithmic, exponential, or power law term for E-wave prediction. Model-based image processing (MBIP) was used for model-predicted flow vs. clinical E-wave comparison using root-mean-square-error (RSME) as an index of goodness-of-fit. RMSE of fits to ≈100 cm/s amplitude E-waves for linear, logarithmic, power law, and exponential relations were indistinguishable [RMSE: 4.1 ± 1.2%, 4.9 ± 1.4%, 5.1 ± 2.0%, and 5.3 ± 1.6% (mean ± SD), respectively]. We conclude that the linear force–length relation is suitable for E-wave based quantitative diastolic function assessment with the added benefit of closed form solutions to the “inverse problem” of diastole. Conversely, it is not possible to distinguish whether a ventricle obeys a linear, power law, exponential, or logarithmic PV relation by MBIP of E-waves.

PV relations echocardiography diastole inverse problem physiologic modeling 

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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Brian S. Oommen
    • 1
  • Mustafa Karamanoglu
    • 1
  • Sándor J. Kovács
    • 1
  1. 1.Cardiovascular Biophysics LaboratoryWashington University School of MedicineSt. Louis

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