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Russian Chemical Bulletin

, Volume 51, Issue 7, pp 1231–1236 | Cite as

Oxidation of ascorbic acid in the presence of phthalocyanine metal complexes. Chemical aspects of catalytic anticancer therapy. 1. Catalysis of oxidation by cobalt octacarboxyphthalocyanine

  • E. G. Girenko
  • S. A. Borisenkova
  • O. L. Kaliya
Article

Abstract

The kinetics of oxidation of ascorbic acid in the presence of cobalt octa-4,5-carboxyphthalocyanine sodium salt (Teraphthal) was studied. A kinetic equation was obtained and a scheme of the process was proposed. According to the scheme, the first stage is the formation of a complex of the catalyst with dioxygen, and the limiting stage is the reaction of dioxygen with the ascorbate monoanion. The influence of the pH of the medium and the presence of a transport protein (albumin) on the state and catalytic activity of Teraphthal was studied. The involvement of hydrogen peroxide and oxygen-centered radicals in the catalytic oxidation of ascorbic acid was proved.

cobalt phthalocyanine ascorbic acid oxidation catalysis anticancer therapy 

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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • E. G. Girenko
    • 1
  • S. A. Borisenkova
    • 2
  • O. L. Kaliya
    • 1
  1. 1.Federal State Unitary Enterprise "State Research Center “Research Institute of Organic Intermediate Products and Dyes,”"MoscowRussian Federation
  2. 2.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

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