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Exploring privileged structures: the combinatorial synthesis of cyclic peptides

  • Douglas A. Horton
  • Gregory T. Bourne
  • Mark L. Smythe
Article

Abstract

Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be considered to be privileged structures. This review outlines the strategies by which both macrocyclic cyclic peptides and cyclic dipeptides or diketopiperazines have been synthesised in combinatorial libraries. It also briefly outlines some of the biological applications of these molecules, thereby justifying their inclusion as privileged structures.

combinatorial chemistry; cyclic peptide; diketopiperazine; library synthesis; piperazine-2,5-dione; privileged structure; ring contraction; solid-phase 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Douglas A. Horton
    • 1
  • Gregory T. Bourne
    • 1
  • Mark L. Smythe
    • 1
    • 2
  1. 1.Institute for Molecular BioscienceThe University of QueenslandSt.LuciaAustralia
  2. 2.Protagonist Pty. Ltd., Level 7 Gehrmann LaboratoriesThe University of QueenslandSt.LuciaAustralia

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