Journal of Chemical Ecology

, Volume 25, Issue 4, pp 935–941

Antifungal Diketopiperazines from Symbiotic Fungus of Fungus-Growing Ant Cyphomyrmex minutus

  • Yong Wang
  • Ulrich G. Mueller
  • Jon Clardy
Article

DOI: 10.1023/A:1020861221126

Cite this article as:
Wang, Y., Mueller, U.G. & Clardy, J. J Chem Ecol (1999) 25: 935. doi:10.1023/A:1020861221126

Abstract

The attine fungus Tyridiomyces formicarum, the symbiont of the fungus-growing ant Cyphomyrmex minutus, produces several antifungal diketopiperazines. This represents the first identification of antifungal compounds from an attine symbiont and contradicts previous suggestions that attine fungi do not produce metabolites with antifungal activity. T. formicarum probably produces antifungal compounds in defense (1) against other fungi that invade the gardens and escape the weeding activity of the ants, or (2) against ant-pathogenic fungi that could harm the host ants. Fungi cultivated by fungus-growing ants may represent a rich source of additional bioactive metabolites.

Antifungal diketopiperazine Cyphomyrmex minutus fungus-growing ant symbiosis Tyridiomyces formicarum 

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Yong Wang
    • 1
    • 2
  • Ulrich G. Mueller
    • 1
  • Jon Clardy
    • 1
  1. 1.Department of Chemistry—Baker LaboratoryCornell UniversityIthaca
  2. 2.Roche Caroline Inc.Florence

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