Journal of Chemical Ecology

, Volume 25, Issue 4, pp 847–859 | Cite as

Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum

  • M. S. Afifi
  • S. A. Ross
  • M. A. ElSohly
  • Z. E. Naeem
  • F. T. Halaweish


Cucurbitacin B, isocucurbitacin B, dihydrocucurbitacin B, cucurbitacin E, dihydrocucurbitacin E, isocucurbitacin D, dihydroisocucurbitacin D, cucurbitacin I, dihydrocucurbitacin I, cucurbitacin Q1, and dihydrocucurbitacin Q1 were identified for the first time as constituents of Cucumis prophetarum L.. Cucurbitacin B, cucurbitacin O, cucurbitacin P, cucurbitacin Q1, dihydrocucurbitacin Q1, isocucurbitacin E, and dihydroisocucurbitacin E also were identified as constituents of C. prophetarum Jusl. ssp. Dissectus. Isocucurbitacin E and dihydroisocucurbitacin E were isolated for the first time in nature. The chemical structures were determined with extensive spectroscopic analysis including 2D NMR, 1H NMR, 13C NMR, correlated spectroscopy (COSY), heteronuclear chemical shift correlation (HETCOR), attached proton test (APT), and distortionless enhancement by polarization transfer (DEPT).

Cucurbitacins isocucurbitacin dihydrocucurbitacin Cucumis prophetarum 


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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • M. S. Afifi
    • 1
  • S. A. Ross
    • 2
  • M. A. ElSohly
    • 2
  • Z. E. Naeem
    • 1
  • F. T. Halaweish
    • 1
  1. 1.Department of Pharmacognosy, Faculty of PharmacyUniversity of MansouraMansouraEgypt
  2. 2.National Center for the Development of Natural Products, Research Institute of Pharmaceutical Sciences. Department of Pharmacognosy, School of PharmacyUniversity of MississippiUniversity

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