Biometals

, Volume 16, Issue 1, pp 185–197

Yeast, a model organism for iron and copper metabolism studies

  • Jeane De Freitas
  • Henri Wintz
  • J Hyoun Kim
  • Helen Poynton
  • Tama Fox
  • Chris Vulpe
Article

DOI: 10.1023/A:1020771000746

Cite this article as:
De Freitas, J., Wintz, H., Hyoun Kim, J. et al. Biometals (2003) 16: 185. doi:10.1023/A:1020771000746

Abstract

Virtually all organisms on earth depend on transition metals for survival. Iron and copper are particularly important because they participate in vital electron transfer reactions, and are thus cofactors of many metabolic enzymes. Their ability to transfer electrons also render them toxic when present in excess. Disturbances of iron and copper steady-state levels can have profound effects on cellular metabolism, growth and development. It is critical to maintain these metals in a narrow range between utility and toxicity. Organisms ranging from bacteria and plants to mammals have developed sophisticated mechanisms to control metal homeostasis. In this review, we will present an overview of the current understanding of iron and copper metabolism in yeast, and the utility of yeast as a model organism to investigate iron and copper metabolism in mammals and plants.

copper iron metabolism metal yeast 

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  • Jeane De Freitas
    • 1
  • Henri Wintz
    • 1
  • J Hyoun Kim
    • 1
  • Helen Poynton
    • 1
  • Tama Fox
    • 1
  • Chris Vulpe
    • 1
  1. 1.Department of Nutritional ScienceUniversity of CaliforniaBerkeleyUSA

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