Heart Failure Reviews

, Volume 7, Issue 4, pp 385–389 | Cite as

Nitric Oxide in Heart Failure: Friend or Foe

  • Bodh I. Jugdutt


Nitric oxide (NO) is a controversial molecule. It is either beneficial or deleterious. As with NO donors, one reason for this duality is related to the dose. Small doses are highly beneficial, maintaining blood flow in vessels and blood pressure, and protecting against foreign invaders. In high doses, it results in hypotension, forms peroxynitrite which is cytotoxic, and contributes to heart failure.

nitric oxide nitroglycerin ischemia infarction heart failure 


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© Kluwer Academic Publishers 2002

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  • Bodh I. Jugdutt

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