Heart Failure Reviews

, Volume 7, Issue 4, pp 359–369 | Cite as

Peroxynitrite in Myocardial Ischemia-Reperfusion Injury

  • Manoj M. Lalu
  • Wenjie Wang
  • Richard Schulz
Article

Abstract

Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion. This review surveys evidence supporting both sides and proposes that peroxynitrite is a dichotomous molecule with beneficial and detrimental effects on the reperfused heart. Its toxic effects are mediated by modification and activation of a variety of targets (including poly (ADP) ribose synthetase and matrix metalloproteinases) while its beneficial effects are primarily mediated through its reaction with thiols, resulting in the formation of NO donor compounds (S-nitrosothiols).

peroxynitrite ischemia-reperfusion myocardium nitric oxide 

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© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Manoj M. Lalu
  • Wenjie Wang
  • Richard Schulz

There are no affiliations available

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