Journal of Clinical Immunology

, Volume 19, Issue 5, pp 314–316 | Cite as

TNF-α and Chronic Fatigue Syndrome

  • Ronald B. Moss
  • Alexander Mercandetti
  • Aristo Vojdani


Based upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-α in patients with CFS. Our results suggest a significant increase serum TNF-α in patients with CFS (P < 0.0001) compared to non-CFS controls. This study supports the further examination of the role of proinflammatory mediators in CFS. Furthermore, the clinical testing of TNF-α blockers and other antiinflammatory agents for the treatment of this disease is warranted.

Chronic fatigue syndrome tumor necrosis factor-α inflammation cytokines 


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Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Ronald B. Moss
    • 1
  • Alexander Mercandetti
    • 2
  • Aristo Vojdani
    • 3
  1. 1.The Immune Response CorporationCarlsbad
  2. 2.Alexander MercandettiSan Diego
  3. 3.Immunosciences Laboratory, Inc.Beverly Hills

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