International Urology and Nephrology

, Volume 33, Issue 4, pp 641–644 | Cite as

Daily variability of serum prostate-specific antigen in men over 50 years of age

  • Ali Tekin
  • Necmettin Atsu
  • Haluk Ozen


In order to investigate the variability ofserum prostate-specific antigen(PSA) levels a total of 44 men 50 years or older with normal digital rectalexamination were enrolled. Blood samples were obtained three times withina day, and, immediately before and 72 hours after hospitalisation.Alterations in serum PSA value during the day and after hospitalisation,which might affect clinical decision, occurred in 15%of the cases withborderline PSA values. The results indicate that there may be significantchanges in serum PSA levels within a day and after hospitalisation.

Daily variation Hospitalisation Prostate-specific antigen 


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  1. 1.
    Akimoto S, Masai M, Shimazaki J. Relationship between diurnal rhythm of serum testosteron and two prostatic markers (PSA and PAP) in untreated prostate cancer. Urology 1994; 42: 337.Google Scholar
  2. 2.
    Catalona WJ, Richie JP, deKernion JB et al. Comparison of prostate specific antigen concentration versus prostate specific antigen density in the early detection of prostate cancer: receiver operating characteristic curves. J Urol 1994; 152: 2031.Google Scholar
  3. 3.
    Cooner WH, Mosley BR, Rutherfold CL Jr et al. Prostate cancer detection in a clinical urological practice by ultrasonography, digital rectal examination and prostate-specific antigen. J Urol 1990; 143: 1146.Google Scholar
  4. 4.
    Dejter SW Jr., Martin JS, McPherson RA, Lynch JH. Daily variability in human serum prostate-specific antigen and prostatic acid phosphatase: a comparative evaluation. Urology 1988; 32: 288.Google Scholar
  5. 5.
    El-Shirbiny AMF, Nilso NT, Pawar HN. Serum prostatespecific antigen: hourly change/24 hours compared with prostatik acid phosphatase. Urology 1990; 35: 88.Google Scholar
  6. 6.
    Komatsu K, Wehner N, Prestigiacomo AF et al. Physiological (intraindividual) variation of serum prostate-specific antigen in 814 men from a screening population. Urology 1996; 47: 343.Google Scholar
  7. 7.
    Maatman TJ. The role of prostate specific antigen as a tumor marker in men with advanced adenocarcinoma of the prostate. J Urol 1989; 141: 1378–1380.Google Scholar
  8. 8.
    Mannini D, Maver P, Aiello E et al. Spontaneous circadian fluctuations of prostate specific antigen and prostatic acid phosphatase activities in patients with prostatic cancer. Urol Res 1988; 16: 9.Google Scholar
  9. 9.
    Oesterling JE. Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 1991; 145: 907.Google Scholar
  10. 10.
    Ornstein DK, Rao GS, Simith DS et al. Effect of digital rectal examination and needle biopsy on serum total and percentage of free prostate specific antigen levels. J Urol 1997; 157: 195.Google Scholar
  11. 11.
    Riehmann M, Rhodes PR, Cook TD et al. Analysis of variation in prostate-specific antigen values. Urology 1993; 42: 390.Google Scholar
  12. 12.
    Schiffman RB, Ahmann FR, Elvick A et al. Analytical and physiological characteristics of prostate-specific antigen and prostatic acid phosphatase in serum compared. Clin Chem 1987; 33: 2086.Google Scholar
  13. 13.
    Simak R, Madersbacher S, Zhang ZF, Maier U. The impact of ejaculation on serum prostate specific antigen. J Urol 1993; 150: 895.Google Scholar
  14. 14.
    Stamey TA, Yang N, Hay AR et al. Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 1987; 317: 909.Google Scholar
  15. 15.
    Winer BJ. Single factor experiments having repeated measures of the same elements. In: Statistical Principles in Experimental Design, 2 ed, 261–308, McGraw-Hill Book Co, New York 1971.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Ali Tekin
    • 1
  • Necmettin Atsu
    • 1
  • Haluk Ozen
    • 1
  1. 1.Department of UrologyHacettepe University, Faculty of MedicineAnkaraTurkey

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