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Digestive Diseases and Sciences

, Volume 47, Issue 11, pp 2523–2530 | Cite as

Breath Ammonia Measurement in Helicobacter pylori Infection

  • David J. Kearney
  • Todd Hubbard
  • David Putnam
Article

Abstract

Our aim was to define the utility of breath ammonia measurement in assessing Helicobacter pylori infection. Volunteers breathed into a device containing three fiberoptic NH3 sensors at baseline and after ingesting 300 mg of urea. Breath ammonia levels were compared to the [14C]urea breath test. Thirteen subjects were tested. Before urea ingestion, H. pylori-positive subjects had significantly lower breath ammonia levels than negative subjects (mean ± sd, 0.04 ppm ± 0.09 vs 0.49 ppm ± 0.24, P = 0.002) and had a significantly greater increases in breath ammonia after urea ingestion (range 198–1494% vs 6–98%). One H. pylori-positive subject underwent treatment and breath ammonia levels shifted from the pattern seen in positive subjects to that seen in negative subjects. In conclusion, breath ammonia measurement for H. Pylori-positive and negative subjects showed distinct patterns. Breath ammonia measurement may be feasible as a diagnostic test for H. pylori.

Helicobacter pylori ammonia 

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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • David J. Kearney
    • 1
    • 2
  • Todd Hubbard
    • 3
  • David Putnam
    • 3
  1. 1.Primary and Specialty Medical Care ServiceVA Puget Sound Health Care SystemSeattleUSA
  2. 2.Department of MedicineUniversity of Washington School of MedicineSeattleUSA
  3. 3.Pacific TechnologiesKirklandUSA

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