Advertisement

Pharmacy World and Science

, Volume 24, Issue 5, pp 175–176 | Cite as

Toxicity to topical dimethyl sulfoxide (DMSO) when used as an extravasation antidote

  • N. CreusEmail author
  • J. Mateu
  • J. Massó
  • C. Codina
  • J. Ribas
Article

Abstract

DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is described. Furthermore, the increasing importance of DMSO pharmacology, as its use in haematologic patients is spreading, is reviewed.

Antidote DMSO Extravasation Stem-cell transplants 

References

  1. 1.
    Don RT. Antidotes to vesicant chemotherapy extravasations. Blood Rev 1990;4:41–60.PubMedGoogle Scholar
  2. 2.
    Olver IN, Aisner J, Hament A, Buchanan L, Bishop JF, Kaplan RS. A prospective study of topical dimethyl sulfoxide for treating anthracycline extravasation. J Clin Oncol 1988;6:1732–5.PubMedGoogle Scholar
  3. 3.
    Bertelli G, Dini D, Forno G, Gozza A, Menturini M, Bellella G, et al. Dimethylsulphoxide and cooling after extravasation of antitumor agents (letter). Lancet 1993;341:1098–9.Google Scholar
  4. 4.
    Mullin S, Beckwith MC, Tyler LS. Prevention and management of antineoplastic extravasation injury. Hosp Pharm 2000;35:57–74.Google Scholar
  5. 5.
    Olver IN, Schwartz MA. The use of dimethyl sulphoxide in limiting tissue damage caused by extravasation of doxorubicin. Cancer Treat Rep 1983;67:407–8 (Letter).PubMedGoogle Scholar
  6. 6.
    Reynolds JEF (Ed). Martindale: the extra pharmacopeia, (electronic version). Denver, Colorado: Micromedex, Inc. 1999.Google Scholar
  7. 7.
    Egorin MJ, Rosen DM, Sridhara R, Sensenbrenner L, Cottler-Fox M. Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants. J Clin Oncol 1998;16:610–5.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • N. Creus
    • 1
    Email author
  • J. Mateu
    • 1
  • J. Massó
    • 1
  • C. Codina
    • 1
  • J. Ribas
    • 1
  1. 1.Pharmacy DepartmentHospital Clinic of BarcelonaBarcelonaSpain

Personalised recommendations