Pharmacy World and Science

, Volume 24, Issue 5, pp 175–176 | Cite as

Toxicity to topical dimethyl sulfoxide (DMSO) when used as an extravasation antidote

  • N. CreusEmail author
  • J. Mateu
  • J. Massó
  • C. Codina
  • J. Ribas


DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is described. Furthermore, the increasing importance of DMSO pharmacology, as its use in haematologic patients is spreading, is reviewed.

Antidote DMSO Extravasation Stem-cell transplants 


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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • N. Creus
    • 1
    Email author
  • J. Mateu
    • 1
  • J. Massó
    • 1
  • C. Codina
    • 1
  • J. Ribas
    • 1
  1. 1.Pharmacy DepartmentHospital Clinic of BarcelonaBarcelonaSpain

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