Neuropsychology Review

, Volume 12, Issue 3, pp 153–177 | Cite as

Neuropsychological Functioning in Chronic Lyme Disease

  • Holly James Westervelt
  • Robert J. McCaffrey


Lyme disease is currently the most common vector-borne illness in the United States. The disease is multisystemic, and chronic disease, in particular, may be associated with neuropsychological deficits. However, to date, only a few empirical studies exist, which examine the neuropsychological sequelae associated with chronic Lyme disease. A review of the literature shows that the deficits observed in adults with chronic Lyme disease are generally consistent with the deficits that can be seen in processes with primarily frontal systems involvement. These observations are generally consistent with neuroradiologic findings. The clinical presentation in chronic Lyme disease and the nature of the neuropsychological deficits are discussed, as are several central issues in understanding neuropsychological functioning in chronic Lyme disease, such as the impact of chronic illness, response to treatment, and the relationship between neuropsychological performance and depression, fatigue, and neurological indicators of disease.

Lyme disease neuroborreliosis neuropsychological functioning chronic illness fatigue 


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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Holly James Westervelt
    • 1
    • 2
  • Robert J. McCaffrey
    • 3
  1. 1.Department of Psychiatry and Human BehaviorBrown Medical SchoolProvidence
  2. 2.Department of PsychiatryRhode Island HospitalProvidence
  3. 3.Department of PsychologyUniversity at Albany, State University of New YorkAlbany

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