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Phenomenology and the Cognitive Sciences

, Volume 1, Issue 2, pp 169–180 | Cite as

Neuronal dynamics and conscious experience: an example of reciprocal causation before epileptic seizures

  • Michel Le Van Quyen
  • Claire Petitmengin
Article

Abstract

Neurophenomenology (Varela 1996) is not only philosophical but also empirical and experimental. Our purpose in this article is to illustrate concretely the efficiency of this approach in the field of neuroscience and, more precisely here, in epileptology. A number of recent observations have indicated that epileptic seizures do not arise suddenly simply as the effect of random fluctuations of brain activity, but require a process of ‘pre-seizure’ changes that start long before. This has been reported at two different levels of description: on the one hand, the epileptic patient often experiences some warning symptoms that precede seizures from several minutes to hours in the form of very specific lived events. On the other hand, the analyses of brain electrical activities have provided strong evidence that it is possible to detect a pre-seizure state in the neuronal dynamics several minutes before the electro-clinical onset of a seizure. We review here some of the ongoing work of our research group concerning seizure anticipation. In particular, we discuss experimental evidence of ‘upward’ (local-to-global) formation of conscious experience and its neural substrate, but also of the “downward” (global-to-local) determination of local neuronal activity by situated conscious activity and its substrate large-scale neural assemblies. This causal role of conscious experience may lead to new kinds of therapy for epileptic patients.

Keywords

Brain Activity Neuronal Activity Electrical Activity Causal Role Recent Observation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Michel Le Van Quyen
    • 1
  • Claire Petitmengin
    • 2
  1. 1.Groupe de Neurodynamique, Laboratoire de Neurosciences Cognitives et Imagerie CérébraleHôpital de la Pitié-SalpêtrièreParisFrance
  2. 2.Institut National des TélécommunicationsEvryFrance

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