Neurochemical Research

, Volume 27, Issue 7–8, pp 601–607 | Cite as

Ceramide in Apoptosis: A Revisited Role

  • Thierry Levade
  • Sophie Malagarie-Cazenave
  • Valérie Gouazé
  • Bruno Ségui
  • Claudine Tardy
  • Susan Betito
  • Nathalie Andrieu-Abadie
  • Olivier Cuvillier


The sphingolipid ceramide has recently emerged as a new transducer or modulator of apoptotic cell death. This function, however, has recently been challenged. Here, in the light of recent observations, the role of ceramide in apoptosis signaling is discussed.

Apoptosis ceramide FAN sphingomyelin sphingomyelinase sphingosine 


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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Thierry Levade
    • 1
  • Sophie Malagarie-Cazenave
    • 1
  • Valérie Gouazé
    • 1
  • Bruno Ségui
    • 1
  • Claudine Tardy
    • 1
  • Susan Betito
    • 1
  • Nathalie Andrieu-Abadie
    • 1
  • Olivier Cuvillier
    • 1
  1. 1.INSERM U.466, Laboratoire de BiochimieToulouseFrance

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