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Pharmaceutical Research

, Volume 10, Issue 3, pp 381–385 | Cite as

Electrochemical Characterization of Human Skin by Impedance Spectroscopy: The Effect of Penetration Enhancers

  • Kyösti Kontturi
  • Lasse Murtomäki
  • Jouni Hirvonen
  • Petteri Paronen
  • Arto Urtti
Article

Abstract

The electrochemical properties of human cadaver skin were studied in a diffusion cell with impedance spectroscopy as a function of time in the absence and presence of penetration enhancers dodecyl N,N-dimethylamino acetate and Azone. An improved electrochemical model of skin is presented, and combining the novel model with modern fractal mathematics, the effect of enhancers on the surface of skin is demonstrated. The enhancers appeared to open new penetration routes and increase the ohmic resistance, capacitive properties, and fractal dimension of skin, which means a rougher or more heterogeneous surface.

transdermal drug delivery impedance spectroscopy human skin penetration enhancers fractal surface 
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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Kyösti Kontturi
    • 1
  • Lasse Murtomäki
    • 1
  • Jouni Hirvonen
    • 2
  • Petteri Paronen
    • 2
  • Arto Urtti
    • 2
  1. 1.Laboratory of Physical Chemistry and ElectrochemistryHelsinki University of TechnologyEspooFinland
  2. 2.Department of Pharmaceutical Technology and A.I. Virtanen InstituteUniversity of Kuopio KuopioFinland

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