Pharmaceutical Research

, Volume 10, Issue 5, pp 774–776 | Cite as

The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride Emulsions

  • Clifford J. Herman
  • Michael J. Groves
phospholipids thermal degradation triglyceride emulsions pH free fatty acids 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    P. K. Hansrani, S. S. Davis, and M. J. Groves. The preparation and properties of sterile intravenous emulsions. J. Parent. Sci. Technol. 37:145–150 (1983).Google Scholar
  2. 2.
    I. Håkansson. Physico-chemical changes in artificial fat emulsions during storage. Acta Chem. Scand. 20:2267–2281 (1966).Google Scholar
  3. 3.
    C. J. Herman. The Influence of Thermal Stress on the Properties of Phospholipid Stabilized Emulsions, Ph.D. thesis, University of Illinois at Chicago, Chicago, 1992.Google Scholar
  4. 4.
    C. Washington and S. S. Davis. Ageing effects in parenteral fat emulsions: The role of fatty acids. Int. J. Pharm. 39:33–37 (1987).Google Scholar
  5. 5.
    J. M. A. Kemps and D. J. A. Crommelin. Chemical stability of phospholipids in pharmaceutical preparations: Hydrolysis of phospholipids in an aqueous medium. Pharm. Weekblad. 123:355–363 (1988).Google Scholar
  6. 6.
    C. J. Herman and M. J. Groves. Hydrolysis kinetics of phospholipids in thermally stressed intravenous lipid emulsion formulations. J. Pharm. Pharmacol. 44:539–542 (1992).Google Scholar
  7. 7.
    M. Grit, J. H. de Smidt, A. Struijke, and D. J. A. Crommelin. Hydrolysis of phosphatidylcholine in aqueous liposome dispersions. Int. J. Pharm. 50:1–6 (1989).Google Scholar
  8. 8.
    D. M. Lidgate, R. C. Fu, and J. S. Fleitman. Using a microfluidizer to manufacture emulsions. BioPharm. 45:28–33 (1989).Google Scholar
  9. 9.
    G. Lee, D. Dick, E. V. Vasquez, and K. Werner. pH measurements of suspensions. In M. H. Rubenstein (ed.), Pharmaceutical Technology: Drug Stability, Ellis Horwood, Chichester, UK, pp. 113–117.Google Scholar
  10. 10.
    C. Paquot. Determination of the acid value and the acidity. In Standard Methods for the Analysis of Oils, Fat, and Derivatives, Pergamon, New York, 1979, pp. 52–55.Google Scholar
  11. 11.
    P. W. Atkins. Physical Chemistry, W. H. Freeman, New York, 1986.Google Scholar

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Clifford J. Herman
    • 1
  • Michael J. Groves
    • 1
  1. 1.Institute for Tuberculosis Research, College of PharmacyUniversity of Illinois at Chicago (M/C 964)Chicago

Personalised recommendations