Digestive Diseases and Sciences

, Volume 42, Issue 9, pp 1940–1949 | Cite as

Tachykinins Influence Interdigestive Rhythm and Contractile Strength of Human Small Intestine

  • Mikael Lordal
  • Elvar Theodorsson
  • Per M. Hellstrom


The effect of the putative entericneurotransmitters neurokinin A and substance P wereinvestigated on human small intestinal motility. Eitherneurokinin A, at doses of 6-25 pmol/kg/min, or substanceP at doses of 1- 6 pmol/kg/min were administeredintravenously to healthy volunteers over 4 hr.Neurokinin A dose-dependently increased the fraction ofphase II of the migrating motor complex, contraction frequency, motility index, and amplitude ofcontractions. At the highest dose, neurokinin A induceda phase II-like pattern, disrupting the migratingmyoelectric complex. Substance P dose-dependentlyincreased phase II of the migrating motor complex. Thecontraction frequency increased slightly at the highestdose, but neither motility index nor contractionamplitude changed. It is concluded that neurokinin A and substance P stimulate small intestinalmotility in man, and it can be speculated that they playa role in the control of human small intestinalmotility.



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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Mikael Lordal
  • Elvar Theodorsson
  • Per M. Hellstrom

There are no affiliations available

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