Digestive Diseases and Sciences

, Volume 43, Issue 6, pp 1226–1229 | Cite as

Beneficial Effects of Helicobacter pylori Eradication on Idiopathic Chronic Urticaria

  • Cristiana Di Campli
  • Antonio Gasbarrini
  • Eleonora Nucera
  • Francesco Franceschi
  • Veronica Ojetti
  • Elena Sanz Torre
  • Domenico Schiavino
  • Paolo Pola
  • Giampiero Patriarca
  • Giovanni Gasbarrini
Article

Abstract

Helicobacter pylori, the most important cause ofgastritis and peptic ulcer, recently has been associatedwith several extradigestive diseases. The aim of thisstudy was to assess the prevalence of Helicobacter pylori infection and the effects of bacteriumeradication in 42 consecutive patients affected byidiopathic chronic urticaria. Helicobacter pylori wasassessed by [13C]urea breath test.Amoxicillin, clarithromycin, and lansoprazole were given to infectedpatients for seven days. Urticaria and gastrointestinalsymptoms were assessed on enrollment and aftereradication. Fifty-five percent of patients proved to beinfected by Helicobacter pylori. Prevalence ofgastrointestinal symptoms did not differ betweeninfected and uninfected patients. Eighty-eight percentof infected patients in whom the bacterium waseradicated after therapy showed a total or partial remission ofurticaria symptoms. Conversely, symptoms remainedunchanged in all uninfected patients. In conclusion,Helicobacter pylori affects a high percentage ofpatients with idiopathic chronic urticaria; however,typical gastrointestinal symptoms do not identifyinfection status. Bacterium eradication is associatedwith a remission of urticaria symptoms, suggesting apossible role of Helicobacter pylori in the pathogenesisof this skin disorder.

H. PYLORI UREA BREATH TEST IDIOPATHIC CHRONIC URTICARIA 

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REFERENCES

  1. 1.
    Pounder RE, Ng D: The prevalence of H. pyloriinfection in different countries. Aliment Pharmacol Ther 9(suppl):33-39, 1995Google Scholar
  2. 2.
    Warren JR, Marshall B: Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1:1273-1275, 1983Google Scholar
  3. 3.
    Graham DY: Campylobacter pyloriand peptic ulcer disease. Gastroenterology 96:614-625, 1989Google Scholar
  4. 4.
    Gasbarrini A, Franceschi F, Gasbarrini G, Pola P: Extrainte stinal pathology associated with Helicobacterinfection. Eur J Gastroente rol Hepatol 9:231-233, 1997Google Scholar
  5. 5.
    Gasbarrini A, Serricchio M, Tondi P, Gasbarrini G, Pola P: Association of H. pyloriinfection with Raynaud phenomenon. Lancet 348:966-967, 1996Google Scholar
  6. 6.
    Mobley HLT: Defining H. pylorias a pathogen: Strain hete rogeneity and virulence. Am J Med 100:2S-11S, 1996Google Scholar
  7. 7.
    Cover TL, Dooley CP, Blaser MJ: Characterization of and human serologic response to proteins in H. pyloribroth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 58:603-610, 1990Google Scholar
  8. 8.
    Champion RH, Roberts SOB, Carpenter RG, Roger JH: Urticaria and angio-oedema. A review of 554 patients. Br J Dermatol 81:588-597, 1969Google Scholar
  9. 9.
    Kaplan AP, Horakova Z, Katz SI: Assessment of tissue fluid histamine levels in patients with urticaria. J Allergy Clin Immunol 61:350-354, 1978Google Scholar
  10. 10.
    Maxwell DL, Atkinson BA, Spur BW, Lessof MH, Lee TH: Skin responses to intradermal histamine and leukotrienes C4, D4 and E4 in patients with chronic idiopathic urticaria and in normal subjects. J Allergy Clin Immunol 86:759-765, 1990Google Scholar
  11. 11.
    Champion RH: A practical approach to urticaria syndromes--a dermatologist's view. Clin Exp Allergy 20:221-224, 1990Google Scholar
  12. 12.
    Crabtree JE: Immune and inflammatory responses to H. pyloriinfection. Scand J Gastroenterol 31(suppl):3-10, 1996Google Scholar
  13. 13.
    Yoshida N, Granger DN, Evans DJ, Graham DY, Anderson DC: Mechanism involved in H. pylori-induced inflammation. Gastroenterology 105:1431-1440, 1993Google Scholar
  14. 14.
    Ahmed A, Holton J, Vaira D, Smith SK, Hoult JRS: Eicosanoid synthesis and H. pylori-associated gastritis: Increase in leukotriene C4 generation associated with H. pyloricolonization. Prostaglandins 44:75-86, 1992Google Scholar
  15. 15.
    Juhlin L, Michaelsson G: Cutaneous reaction to kallikrein, bradykinin and histamine in healthy subjects and in patients with urticaria. Acta Derm Venereol 49:26-36, 1969Google Scholar
  16. 16.
    Galli SJ: New insights into the riddle of mast cells: environmental regulation of mast cell development and phenotypic hete rogeneity. Lab Invest 62:5-33, 1990Google Scholar
  17. 17.
    Gruber BL, Baeza ML, Marchese MJ, Agnello V, Kaplan AP: Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J Invest Dermatol 90:213-217, 1988Google Scholar
  18. 18.
    Hide M, Francis DM, Grattan CEH, Hakimi J, Kochan JP, Graeves MW: Autoantibodies against the high affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 328:1599-1604, 1993Google Scholar
  19. 19.
    Rumbyrt JS, Katz JL, Schocket AL: Resolution of chronic urticaria in patients with thyroid autoimmunity. J Allergy Clin Immunol 96:901-905, 1995Google Scholar
  20. 20.
    Figura N, Guarino A, Gragnoli A: H. pyloriinfection and thyroid diseases. Gut 39(suppl):A93, 1996 (abstract)Google Scholar
  21. 21.
    Rebora A, Drago F, Parodi A: May H. pyloribe important for dermatologists? Dermatology 191:6-8, 1995Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Cristiana Di Campli
  • Antonio Gasbarrini
  • Eleonora Nucera
  • Francesco Franceschi
  • Veronica Ojetti
  • Elena Sanz Torre
  • Domenico Schiavino
  • Paolo Pola
  • Giampiero Patriarca
  • Giovanni Gasbarrini

There are no affiliations available

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