Digestive Diseases and Sciences

, Volume 42, Issue 11, pp 2378–2383 | Cite as

Submandibular Gland Peptide-T (SGP-T) Inhibits Intestinal Anaphylaxis

  • Ronald Mathison
  • Daimen Tan
  • Mark Oliver
  • Dean Befus
  • Brent Scott
  • Joseph S. Davison

Abstract

A novel peptide, submandibular gland peptide-T(SGP-T), which reduces allergen-induced hypotension, wasexamined for effects on intestinal anaphylaxis.Hooded-Lister rats were sensitized to egg albumin and prepared for the measurement of in vivomyoelectric activity of the jejunum. The disruption ofmigrating myoelectric complexes (MMCs) that occurs uponintraluminal, duodenal challenge with antigen of sensitized rats was inhibited by 75% uponintravenous treatment with 100 μg/kg of SGP-T. Inaddition, SGP-T reduced the number of rats experiencinganaphylactic diarrhea and disrupted MMCs, but thepeptide did not alter antigen-provoked release of ratmast cell protease II. The mechanism of action of SGP-Tremains to be determined, but it apparently does not actdirectly on mast cells to exert its antianaphylactic action. These results emphasize that modulationof immediate hypersensitivity reactions is only one ofseveral gastrointestinal activities that are affected bygrowth factors and peptides released from salivary glands.

FOOD ALLERGY IMMEDIATE HYPERSENSITIVITY MIGRATING MYOELECTRIC COMPLEXES SALIVARY GLANDS 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Ronald Mathison
  • Daimen Tan
  • Mark Oliver
  • Dean Befus
  • Brent Scott
  • Joseph S. Davison

There are no affiliations available

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