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Digestive Diseases and Sciences

, Volume 42, Issue 12, pp 2463–2467 | Cite as

p53 Expression in Gastric Cancer (Clinicopathological Correlation and Prognostic Significance)

  • S.P. Monig
  • S. Eidt
  • T.K. Zirbes
  • D. Stippel
  • S.E. Baldus
  • H. Pichlmaier
Article

Abstract

For evaluation of the prognostic relevance ofp53 expression in gastric cancer, theimmunohistochemical tissue status of 133 primary gastriccancer patients was investigated for p53 expression andthe association between p53 tissue status andclinicopathological parameters was analyzed. P53immunoreactivity was detected in the nuclei of cancercells in 35 cases (26.3%). The nuclear p53immunoreaction was closely associated with tumor location, lymph nodemetastasis, and curability. Tumors with positive p53stain reactions frequently metastasized to lymph nodes(metastatic rate: 91.4%) in contrast to tumors with negative p53 stain reactivity (71.4%, P =0.021). Immunohistochemical analysis of primary gastriccancer appears to be an accurate and simple method ofscreening for p53 expression. In combination with common prognostic parameters, determination of p53tissue status might help to detect prognosticallyunfavorable subgroups of gastric cancerpatients.

GASTRIC CANCER p53 IMMUNOHISTOCHEMISTRY LYMPH NODE METASTASIS 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • S.P. Monig
  • S. Eidt
  • T.K. Zirbes
  • D. Stippel
  • S.E. Baldus
  • H. Pichlmaier

There are no affiliations available

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