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Growth Hormone-Releasing Hormone (GRH)-Producing Pancreatic Tumor with No Evidence of Multiple Endocrine Neoplasia Type 1

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REFERENCES

  1. Faglia G, Arosia M, Bazzoni N: Ectopic acromegaly. Endocrinol Metab Clin North Am 21:575–595, 1992

    Google Scholar 

  2. Beck C, Larkins RG, Martin TJ: Stimulation of growth hormone release from superfused rat pituitary by extracts of hypothalamus and of human lung tumors. J Endocrinol 59:325–333, 1973

    Google Scholar 

  3. Frohman LA, Szabo M, Berelowitz M, Stachura ME: Partial purification and characterization of a peptide with growth hormone releasing activity from extrapituitary tumors in patients with acromegaly. J Clin Invest 65:43–54, 1980

    Google Scholar 

  4. Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB: Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 218:585–587, 1982

    Google Scholar 

  5. Rivier J, Spiess J, Thorner M, Vale W: Characterization of a growth hormone-releasing factor from a human pancreatic islet tumor. Nature 300:276–278, 1982

    Google Scholar 

  6. Caplan RH, Koob L, Abellera RM, Pagliara AS, Kovacs K, Randall RV: Cure of acromegaly by operative removal of an islet cell tumor of the pancreas. Am J Med. 64:874–822, 1978

    Google Scholar 

  7. Thorner MO, Perryman RL, Cronin MJ, Rogol AD, Draznin RM, Johansen A, Vale W, Horvath E, Kovacs K: Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest 70:965–977, 1982

    Google Scholar 

  8. Berger G, Trouillas J, Bloch B, Sassolas G, Berger F, Partensky C, Chayvialle JA, Brazeau P, Claustrat B, Lesbros F, Giros C: Multihormonal carcinoid tumor of the pancreas. Secreting growth hormone-releasing factor as a cause of acromegaly. Cancer 54:2097–2108, 1984

    Google Scholar 

  9. Wilson DM, Ceda GP, Bostwick DG, Webber RJ, Minkoff JR, Pont A, Hintz RL, Bensch JG, Kraemer FB, Rosenfeld RG, Hoffman AR: Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor. J Clin Endocrinol Metab 59:1002–1005, 1984

    Google Scholar 

  10. Sasaki A, Sato S, Hnuyu K, Go M, Shimizu Y, Murakami O, Mouri T, Yoshinaga K, Sasano N: Acromegaly associated with an ectopic GRF producing pancreatic carcinoid tumor: characterization of immunoreactive GRF in pancreatic tumor. J Clin Exp Med 135:909–910, 1985 (in Japanese)

    Google Scholar 

  11. Ch'ng JLC, Christofides ND, Kraenzlin ME, Keshavarzian A, Burrin JM, Woolf IL, Hodgson HJF, Bloom SR: Growth hormone secretion dynamics in a patient with ectopic growth hormone-releasing factor production. Am J Med 79:135–138, 1985

    Google Scholar 

  12. Saeger W, Schulte HM, Kloeppel G: Morphology of a GHRH producing pancreatic islet cell tumour causing acromegaly. Virchows Arch (Pathol Anat) 409:547–554, 1986

    Google Scholar 

  13. Sano T, Yamasaki R, Saito H, Hirose T, Kudo E, Kameyama K, Hiraishi K, Saito S, Hizawa K: Growth hormone-releasing hormone (GHRH)-secreting pancreatic tumor in patient with multiple endocrine neoplasia type 1. Am J Surg Pathol 11:810–815, 1987

    Google Scholar 

  14. Ramsay JA, Kovacs K, Asa SL, Pike MJ, Thorner MO: Reversible sellar enlargement due to growth hormone-releasing hormone production by pancreatic endocrine tumor in an acromegalic patient with multiple endocrine neoplasia type I syndrome. Cancer 62:445–450, 1988

    Google Scholar 

  15. Genka S, Soeda H, Takahashi M, Katakami H, Sanno N, Osamura Y, Fuchinoue T, Teramoto A: Acromegaly, diabetes insipidus and visual loss caused by metabolic growth hormone-releasing-hormone (GRH)-producing malignant pancreatic endocrine tumor in the pituitary gland. J Neurosurg 83:719–723, 1995

    Google Scholar 

  16. Ohyama K, Fujimoto M, Nakagomi Y, Kato K: Clinical availability of radioimmunoassay of plasma growth hormone releasing factor. J Jpn Pediatr Soc 91:1358–1365, 1987 (in Japanese)

    Google Scholar 

  17. Osamura RY, Oda K, Utsunomiya H, Inada K, Katakami H, Voss JW, Mayo K, Rosenfeld MG: Immunohistochemical expression of pit-1 protein in pituitary glands of human GRF transgenic mice: Its relationship with hormonal expressions. Endocrine J 40:133–139, 1993

    Google Scholar 

  18. Sano T, Asa S, Kovacs K: Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocrine Rev 9:357–373, 1988

    Google Scholar 

  19. Thakker RV: The molecular genetics of the multiple endocrine neoplasia syndromes. Clin Endocrinol 38:1–14, 1993

    Google Scholar 

  20. Pepine CJ, Aloia J: Heart muscle disease in acromegaly. Am J Med 48:530–534, 1970

    Google Scholar 

  21. Mather HM, Boyd MJ, Jenkins JS: Heart size and function in acromegaly. Br Heart J 4:697–701, 1979

    Google Scholar 

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Authors
  1. S. Kawa
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  2. T. Ueno
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  3. A. Iijima
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  4. T. Midorikawa
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  5. Y. Fujimori
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  6. M. Tokoo
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  7. H. Oguchi
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  8. K. Kiyosawa
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  9. Y. Imai
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  10. G. Kaneko
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  11. T. Kuroda
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  12. K. Hashizume
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  13. R.Y. Osamura
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  14. H. Katakami
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Kawa, S., Ueno, T., Iijima, A. et al. Growth Hormone-Releasing Hormone (GRH)-Producing Pancreatic Tumor with No Evidence of Multiple Endocrine Neoplasia Type 1. Dig Dis Sci 42, 1480–1485 (1997). https://doi.org/10.1023/A:1018818811199

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