Digestive Diseases and Sciences

, Volume 42, Issue 5, pp 1070–1075 | Cite as

Gastric Lipase Secretion After Sham Feeding and Cholinergic Blockade

  • Morten Wojdemann
  • Ole Olsen
  • Peter Norregaard
  • Berit Sternby
  • Jens F. Rehfeld


Our purpose was to examine gastric lipasesecretion after cephalic stimulation (sham feeding) andto examine the effect of cholinergic blockade. Eighthealthy volunteers, four women and four men, age 21-58 years, were studied twice on separate days.They were sham fed with and without infusion ofatropine. Gastric content was measured and the amount aswell as the activity of gastric lipase output weredetermined. Plasma concentrations of gastrin, secretin, andcholecystokinin (CCK) were measured simultaneously byradioimmunoassays. Cephalic stimuli can evoke humangastric lipase secretion, and this effect was almost ablated by atropine blockade of cholinergicreceptors. The concentrations of CCK and secretin inplasma were unaffected by sham feeding with or withoutatropine blockade, whereas gastrin was stimulated by sham feeding after atropine blockade.Gastric lipase secretion in man is apparently controlledby interacting vagal and hormonal mechanisms.



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  1. 1.
    Carriere F, Barrowman JA, Verger R, Laugier R: Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Gastroenterology 105:876-888, 1993Google Scholar
  2. 2.
    Wøjdemann M, Nørregaard P, Sternby B, Worning H, Olsen O: Low doses of pentagastrin stimulate gastric lipase secretion in man. Scand J Gastroenterol 30:631-634, 1995Google Scholar
  3. 3.
    Riber C, Højgaard L, Madsen JL, Rehfeld JF, Olsen O: Gallbladder emptying and CCK response to fish oil and trioleate ingestion. Digestion 57(3):161-164Google Scholar
  4. 4.
    Gargouri Y, Pieroni G, Riviere C, Sauniere J-F, Lowe PA, Sarda L, Verger R: Kinetic assay of human gastric lipase on short-and long-chain triacylglycerol emulsions. Gastroenterology 91:919-925, 1986Google Scholar
  5. 5.
    Rehfeld J, Stadil F, Rubin B: Production and evaluation of antibodies for the radioimmunoassay of gastrin. Scand J Clin Invest 30:221-232, 1972Google Scholar
  6. 6.
    Stadil F, Rehfeld J: Determination of gastrin in serum. Scand J Gastroenterol 8:101-112, 1973Google Scholar
  7. 7.
    Schaffalitzky de Muckadell OB, Fahrenkrug J: Radioimmunoassay of secretin in plasma. Scand J Clin Lab Invest 37:155-162, 1977Google Scholar
  8. 8.
    Schaffalitzky de Muckadell OB, Fahrenkrug J, Westphall I, Worning H: Meal-stimulated secretin release in man: Effect of acid and bile. Scand J Gastroenterol 16:981-988, 1981Google Scholar
  9. 9.
    Cantor P: Evaluation of a radioimmunoassay for cholecystokinin in human plasma. Scand J Clin Invest 46:213-217, 1986Google Scholar
  10. 10.
    Henriksen FW, Jørgensen SP, Møller S: Interaction between secretin and cholecystokinin on inhibition of gastric secretion in man. Scand J Gastroenterol 9:735-740, 1974Google Scholar
  11. 11.
    Faber RG, Russel RCG, Royston CMS, Whitfield P, Hobsley M: Duodenal reflux during insulin-stimulated secretin. Gut 15:880-884, 1974Google Scholar
  12. 12.
    Wøjdemann M, Olsen O, Larsen S, Sternby B, Rehfeld JF: Deficient gastric lipase secretion in pancreatic insufficiency. Scand J Gastroenterol (in press)Google Scholar

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Morten Wojdemann
  • Ole Olsen
  • Peter Norregaard
  • Berit Sternby
  • Jens F. Rehfeld

There are no affiliations available

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