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Digestive Diseases and Sciences

, Volume 42, Issue 5, pp 1070–1075 | Cite as

Gastric Lipase Secretion After Sham Feeding and Cholinergic Blockade

  • Morten Wojdemann
  • Ole Olsen
  • Peter Norregaard
  • Berit Sternby
  • Jens F. Rehfeld
Article

Abstract

Our purpose was to examine gastric lipasesecretion after cephalic stimulation (sham feeding) andto examine the effect of cholinergic blockade. Eighthealthy volunteers, four women and four men, age 21-58 years, were studied twice on separate days.They were sham fed with and without infusion ofatropine. Gastric content was measured and the amount aswell as the activity of gastric lipase output weredetermined. Plasma concentrations of gastrin, secretin, andcholecystokinin (CCK) were measured simultaneously byradioimmunoassays. Cephalic stimuli can evoke humangastric lipase secretion, and this effect was almost ablated by atropine blockade of cholinergicreceptors. The concentrations of CCK and secretin inplasma were unaffected by sham feeding with or withoutatropine blockade, whereas gastrin was stimulated by sham feeding after atropine blockade.Gastric lipase secretion in man is apparently controlledby interacting vagal and hormonal mechanisms.

CHOLECYSTOKININ CHOLINERGIC BLOCKADE GASTRIC LIPASE GASTRIN SECRETIN SHAM FEEDING 

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Morten Wojdemann
  • Ole Olsen
  • Peter Norregaard
  • Berit Sternby
  • Jens F. Rehfeld

There are no affiliations available

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