Gastric Lipase Secretion After Sham Feeding and Cholinergic Blockade
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Our purpose was to examine gastric lipasesecretion after cephalic stimulation (sham feeding) andto examine the effect of cholinergic blockade. Eighthealthy volunteers, four women and four men, age 21-58 years, were studied twice on separate days.They were sham fed with and without infusion ofatropine. Gastric content was measured and the amount aswell as the activity of gastric lipase output weredetermined. Plasma concentrations of gastrin, secretin, andcholecystokinin (CCK) were measured simultaneously byradioimmunoassays. Cephalic stimuli can evoke humangastric lipase secretion, and this effect was almost ablated by atropine blockade of cholinergicreceptors. The concentrations of CCK and secretin inplasma were unaffected by sham feeding with or withoutatropine blockade, whereas gastrin was stimulated by sham feeding after atropine blockade.Gastric lipase secretion in man is apparently controlledby interacting vagal and hormonal mechanisms.
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