Digestive Diseases and Sciences

, Volume 43, Issue 9, pp 2028–2033 | Cite as

Disturbed Solid-Phase Gastric Emptying in Functional Dyspepsia (A Meta-Analysis)

  • A. O. Quarter
  • N. J. De Wit
  • A. C. Lodder
  • M. E. Numans
  • A. J. P. M. Smout
  • A. W. Hoes


Functional dyspepsia is a common disorder witha diverse pathophysiological background, but the role ofmotility disorders in functional dyspepsia remainsunclear. We aimed to quantify the relationship between disturbed gastric emptying andfunctional dyspepsia, using a meta-analytic approach.Through a structured literature search of Medline andEmbase from 1983 to 1996, we selected all studies inwhich scintigraphic solid-phase gastric emptying wasmeasured in both functional dyspeptic patients andcontrols. Seventeen studies involving 868 dyspepticpatients and 397 controls were pooled. Gastric emptying in patients with functional dyspepsia was 1.46(1.23-1.69) times slower than controls; the proportionof patients with abnormally slow emptying was either 37%(34-40%, simple numeric pooling) or 39% (29-49%,weighted pooling). We conclude that gastric emptying ofsolids in patients with functional dyspepsia is 1.5times slower than in healthy controls and that asignificant delay of emptying is present in almost 40% of patients with functionaldyspepsia.



Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Knill-Jones RP: Geographical differences in the prevalence of dyspepsia. Scand J Gastroenterol 26( suppl 182):17–22, 1991Google Scholar
  2. 2.
    Jones R, Lydeard S: Prevalence of symptoms of dyspepsia in the community. Br Med J 298:30–32, 1989Google Scholar
  3. 3.
    Klauser AG, Voderholzer WA, Knesewitsch PA, Schindlbeck NE: What is behind dyspepsia? Dig Dis Sci 38(1):147–154, 1993PubMedGoogle Scholar
  4. 4.
    Jian R, Ducrot F, Piedeloup C, Mary JY, Najean Y, Bernie r JJ: Measurement of gastric emptying in dyspeptic patients: Effect of a new gastrokinetic agent (cisapride ). Gut 26:352–358, 1985PubMedGoogle Scholar
  5. 5.
    Heading RC, Bolondi L, Camilleri M, Corinaldesi R, Horowitz M, Jian R, Scarpignato C: Gastric emptying. Gastroenterol Int 5(4):203–215, 1992Google Scholar
  6. 6.
    Parkman H, Harris AD, Krevsky B, Urbain J-L, Maurer AH, Fisher RS: Gastroduodenal motility and dysmotility: An update on techniques available for evaluation. Am J Gastroenterol 90(6):869–892, 1995PubMedGoogle Scholar
  7. 7.
    Smout A, Horrowitz M, Armstrong D: Methods to study gastric emptying. Dig Dis Sci 39( suppl):130S–132S, 1994PubMedGoogle Scholar
  8. 8.
    Rao CR: Linear statistical inference and its applications. New York, Wiley & Sons, 1973, pp 388–389Google Scholar
  9. 9.
    DerSimonian R, Laird N: Meta analysis in clinical trials. Controlled Clin Trials 7:177–188, 1986PubMedGoogle Scholar
  10. 10.
    Heikkinen M, Pikkarainen P, Takala J, Rasanen H, Julkunen R: Etiology of dyspepsia: Four hundred unselected consecutive patients in general practice. Scand J Gastroenterol 30:519–523, 1995PubMedGoogle Scholar
  11. 11.
    Hö lzer HH, Raybould HE: Vagal and splanchnic sensory pathways mediate inhibition of gastric motility induced by duodenal distension. Am J Physiol 262:G603–G608, 1992PubMedGoogle Scholar
  12. 12.
    Youle MS, Read NW: Effect of painless re ctal distension on gastrointestinal transit of a solid meal. Dig Dis Sci 29:902–906, 1984PubMedGoogle Scholar
  13. 13.
    Tjee rdsma HC, Smout AJPM, Akkermans LMA: Voluntary suppression of defecation delays gastric emptying. Dig Dis Sci 38:832–836, 1993PubMedGoogle Scholar
  14. 14.
    Watson RGP, Love AHG: Gastric emptying in patients with flatulent dyspepsia, with and without gallbladder disease. Scand J Gastroenterol 22:47–53, 1987PubMedGoogle Scholar
  15. 15.
    Wegener M, Börsch G, Schaffstein J, Schulz-Flake C, Mai U, Leverkus F: Are dyspeptic symptoms in patients with Campylobacter pyloriassociated type-B gastritis linked to delayed gastric emptying? Am J Gastroenterol 83:737–740, 1988PubMedGoogle Scholar
  16. 16.
    Urbain J-LC, Siege l JA, De bie NC, Pauwels SP: Effect of cisapride on gastric emptying in dyspeptic patients. Dig Dis Sci 33:779–783, 1988PubMedGoogle Scholar
  17. 17.
    Talley NJ, Shuter B, McCrudden G, Jones M, Hoschl R, Piper DW: Lack of association between gastric emptying of solids and symptoms in nonulcer dyspepsia. J Clin Gastroenterol 11:625–630, 1989PubMedGoogle Scholar
  18. 18.
    Jian R, Ducrot F, Ruskone A, Chaussade S, Rambaud JC, Modigliani R, Rain JD, Bernier JJ: Symptomatic, radionuclide and therapeutic assessment of chronic idiopathic dyspepsia. Dig Dis Sci 34:657–664, 1989PubMedGoogle Scholar
  19. 19.
    Waldron B, Cullen PT, Kumar R, Smith D, Jankowski J, Hopwood D, Sutton D, Kennedy N, Campbell FC: Evidence for hypomotility in nonulcer dyspepsia: A prospective multifactorial study. Gut 32:246–251, 1991PubMedGoogle Scholar
  20. 20.
    Lémann M, Dederding JP, Flourié B, Franchisseur C, Rambaud JC, Jian R: Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia. Dig Dis Sci 36:1249–1254, 1991PubMedGoogle Scholar
  21. 21.
    Chua A, Keating J, Hamilton D, Keeling PWN, Dinan TG: Central serotonin receptors and delayed gastric emptying in nonulcer dyspepsia. Br Med J 305:280–282, 1992Google Scholar
  22. 22.
    Tucci A, Corinaldesi R, Stanghellini V, Tosetti C, di Febo G, Paparo GF, et al: Helicobacter pyloriinfection and gastric function in patients with chronic idiopathic dyspepsia. Gastroente rology 103:768–774, 1992Google Scholar
  23. 23.
    Scott AM, Kellow JE, Shuter B, Cowan H, Corbett A-M, Riley JW, et al: Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia. Dig Dis Sci 38:2247–2254, 1993PubMedGoogle Scholar
  24. 24.
    Caballero-Plasencia AM, Muros-Navarro MC, Martin-Ruiz JL, Valenzue la-Barranco M, de los Reyes-Garcia MC, Vilchez-Joya R, et al: Gastroparesis of digestible and indigestible solids in patients with insulin-dependent diabetes mellitus or functional dyspepsia. Dig Dis Sci 39:1409–1415, 1994PubMedGoogle Scholar
  25. 25.
    Troncon LEA, Bennett RJM, Ahluwalia NK, Thompson DG: Abnormal intragastric distribution of food during gastric emptying in functional dyspepsa patients. Gut 35:327–332, 1994PubMedGoogle Scholar
  26. 26.
    Su Y-C, Jan C-M, Wang W-M, Chen L-T, Wu D-C, Liu C-S, et al: Doe s Helicobacter pyloriinfection play a role in the pathogenesis of nonulcer dyspepsia— a study of gastric emptying time. Kaohsiung J Med Sci 11:8–14, 1995Google Scholar
  27. 27.
    Urbain JLC, Vekemans MC, Parkman H, v Cauteren J, Mayeur SM, vd Mae ghdenbergh V, e t al: Dynamic antral scintigraphy to characterize gastric antral motility in functional dyspepsia. J Nucl Med 36:1579–1586, 1995PubMedGoogle Scholar
  28. 28.
    Stanghellini V, Tosetti C, Paternico A, Barbara G, Morselli-Labate AM, Monetti N, et al: Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 110:1036–1042, 1996Google Scholar
  29. 29.
    Chang C-S, Chen G-H, Kao C-H, Wang S-J, Peng S-N, Huang C-K: The effect of Helicobacter pyloriinfection on gastric emptying of digestible and indigestible solids in patients with nonulcer dyspepsia. Am J Gastroenterol 91:474–479, 1996PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • A. O. Quarter
  • N. J. De Wit
  • A. C. Lodder
  • M. E. Numans
  • A. J. P. M. Smout
  • A. W. Hoes

There are no affiliations available

Personalised recommendations