Structural Cues from the Tissue Microenvironment Are Essential Determinants of the Human Mammary Epithelial Cell Phenotype

  • Karen L. Schmeichel
  • Valerie M. Weaver
  • Mina J. Bissell


Historically, the study of normal human breastfunction and breast disorders has been significantlyimpaired by limitations inherent to available modelsystems. Recent improvements in human breast epithelial cell lines and three-dimensional(3-D)3 culture systems have contributed tothe development of in vitro model systems thatrecapitulate differentiated epithelial cell phenotypeswith remarkable fidelity. Molecular characterization of these humanbreast cell models has demonstrated that normal breastepithelial cell behavior is determined in part by theprecise interplay that exists between a cell and its surrounding microenvironment. Recent functionalstudies of integrins in a human model system provideevidence to support the idea that the structuralstability afforded by integrin-mediatedcell-extracellular matrix interactions is an important determinantof normal cellular behavior, and that alterations intissue structure can give rise to tumorigenicprogression.



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© Plenum Publishing Corporation 1998

Authors and Affiliations

  • Karen L. Schmeichel
  • Valerie M. Weaver
  • Mina J. Bissell

There are no affiliations available

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