Advertisement

Glycoconjugate Journal

, Volume 14, Issue 5, pp 577–584 | Cite as

Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer

  • Reiji Kannagi
Article

Abstract

The carbohydrate determinants, sialyl Lewis A and sialyl Lewis X, which are frequently expressed on human cancer cells, serve as ligands for a cell adhesion molecule of the selectin family, E-selectin, which is expressed on vascular endothelial cells. These carbohydrate determinants are involved in the adhesion of cancer cells to vascular endothelium and thus contribute to hematogenous metastasis of cancer. The initial adhesion mediated by these molecules triggers activation of integrin molecules through the action of several cytokines and leads to the extravasation of cancer cells. Cancer cells also produce humoral factors that facilitate E-selectin expression on endothelial cells. The degree of expression of the carbohydrate ligands at the surface of cancer cells is well correlated with the frequency of hematogenous metastasis and prognostic outcome of patients with cancers. The alteration of glycosyltransferase activities that leads to the enhanced expression of these carbohydrate ligands on cancer cell surface are currently being investigated.

Sialyl Lewis A sialyl Lewis X selectin metastasis cell adhesion cancer 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Takada A, Ohmori K, Takahashi N, Tsuyuoka K, Yago K, Zenita K, Hasegawa A, Kannagi R (1991) Biochem Biophys Res Commun 179: 713–19.PubMedCrossRefGoogle Scholar
  2. 2.
    Takada A, Ohmori K, Yoneda T, Tsuyuoka K, Hasegawa A, Kiso M, Kannagi R (1993) Cancer Res 53: 354–61.PubMedGoogle Scholar
  3. 3.
    Majuri M-L, Mattila P, Renkonen R (1992) Biochem Biophys Res Commun 182: 1376–82.PubMedCrossRefGoogle Scholar
  4. 4.
    Merwin JR, Madri JA, Lynch M (1992) Biochem Biophys Res Commun 189: 315–23.PubMedCrossRefGoogle Scholar
  5. 5.
    Zaifert K, Cohen MC (1993) Clin Immunol Immunopathol 68: 51–56.PubMedCrossRefGoogle Scholar
  6. 6.
    Lowe JB, Stoolman LM, Nair RP, Larsen RD, Berhend TL, Marks RM (1990) Cell 63: 475–84.PubMedCrossRefGoogle Scholar
  7. 7.
    Phillips ML, Nudelman E, Gaeta FCA, Perez M, Singhal AK, Hakomori S, Paulson JC (1990) Science 250: 1130–32.PubMedCrossRefGoogle Scholar
  8. 8.
    Walz G, Aruffo A, Kolanus W, Bevilacqua M, Seed B (1990) Science 250: 1132–35.PubMedCrossRefGoogle Scholar
  9. 9.
    Tyrrell D, James P, Rao N, Foxall C, Abbas S, Dasgupta F, Nashed M, Hasegawa A, Kiso M, Asa D, Kidd J, Brandley BK (1991) Proc Natl Acad Sci USA 88: 10372–76.PubMedCrossRefGoogle Scholar
  10. 10.
    Berg EL, Robinson MK, Mansson O, Butcher EC, Magnani JL (1991) J Biol Chem 266: 14869–72.PubMedGoogle Scholar
  11. 11.
    Dejana E, Martin Padura I, Lauri D, Bernasconi S, Bani MR, Garofalo A, Giavazzi R, Magnani J, Mantovani A, Menard S (1992) Lab Invest 66: 324–30.PubMedGoogle Scholar
  12. 12.
    Kannagi R, Kitahara A, Itai S, Zenita K, Shigeta K, Tachikawa T, Noda A, Hirano H, Abe M, Shin S, Fukushi Y, Hakomori S, Imura H (1988) Cancer Res 48: 3856–63.PubMedGoogle Scholar
  13. 13.
    Itai S, Nishikata J, Yoneda T, Ohmori K, Tsunekawa S, Hiraiwa N, Yamabe H, Arii S, Tobe T, Kannagi R (1991) Cancer 67: 1576–87.PubMedCrossRefGoogle Scholar
  14. 14.
    Miyake M, Zenita K, Tanaka O, Okada Y, Kannagi R (1988) Cancer Res 48: 715–58.Google Scholar
  15. 15.
    Zenita K, Kirihata Y, Kitahara A, Shigeta K, Higuchi K, Hirashima K, Murachi T, Miyaka M, Takeda T, Kannagi R (1988) Int J Cancer 41: 344–49.PubMedGoogle Scholar
  16. 16.
    Kannagi R, Fukushi Y, Tachikawa T, Noda A, Shin S, Shigeta K, Hiraiwa N, Fukuda Y, Inamoto T, Hakomori S, Imura H (1986) Cancer Res 46: 2619–26.PubMedGoogle Scholar
  17. 17.
    Iwai K, Ishikura H, K aji M, Sugiura H, Ishizu A, Takahashi C, Kato H, Tanabe T, Yoshiki T (1993) Int J Cancer 54: 972–77.PubMedGoogle Scholar
  18. 18.
    Ohmori K, Takada A, Ohwaki I, Takahashi N, Furukawa Y, Maeda M, Kiso M, Hasegawa A, Kannagi M, Kannagi R (1993) Blood 82(9): 2797–805.PubMedGoogle Scholar
  19. 19.
    Furukawa Y, Tara M, Ohmori K, Kannagi R (1994) Cancer Res 54: 6533–38.PubMedGoogle Scholar
  20. 20.
    Kannagi R, Magnani JL (1995) in Leukocyte Typing V (Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, Ritz J, Shaw S, Silverstein R, Springer T, Tedder TF, Todd RF, eds) pp 1529–1531. Oxford: Oxford University Press.Google Scholar
  21. 21.
    Matsushita Y, Cleary KR, Ota DM, Hoff SD, Irimura T (1990) Lab Invest 63: 780–91.PubMedGoogle Scholar
  22. 22.
    Shirahama T, Ikoma M, Muramastu T, Ohi Y (1992) J Urol 148: 1319–22.PubMedGoogle Scholar
  23. 23.
    Nakamori S, Kameyama M, Imaoka S, Furukawa H, Ishikawa O, Sasaki Y, Kabuto T, Iwanaga T, Matsushita Y, Irimura T (1993) Cancer Res 53: 3632–37.PubMedGoogle Scholar
  24. 24.
    Kiriyama K, Watanabe T, Sakamoto J, Ito K, Akiyama S, Yamauchi M, Takagi H (1991) Nippon Geka Gakkai Zasshi 92: 320–30 (in Japanese).PubMedGoogle Scholar
  25. 25.
    Kiriyama K, Watanabe T (1994) in Complex Carbohydrates (Kannagi R, ed.) pp 67–76. Tokyo: Medical View Inc. (in Japanese).Google Scholar
  26. 26.
    Shimono R, Mori M, Akazawa K, Adachi Y, Sugimachi K (1994) Am J Gastroenterol 89: 101–5.PubMedGoogle Scholar
  27. 27.
    Nakayama T, Watanabe M, Katsumata T, Teramoto T, Kitajima M (1995) Cancer 75: 2051–56.PubMedCrossRefGoogle Scholar
  28. 28.
    Narita T, Funahashi H, Satoh Y, Watanabe T, Sakamoto J, Takagi H (1993) Cancer 71: 3044–53.PubMedCrossRefGoogle Scholar
  29. 29.
    Ye C, Kiriyama K, Mitsuoka C, Kannagi R, Ito K, Watanabe T, Kondo K, Akiyama S, Takagi H (1995) Int J Cancer 61: 455–60.PubMedGoogle Scholar
  30. 30.
    Narita T, Kawakami-Kimura N, Kasai Y, Hosono J, Nakashio T, Matsuura N, Sato M, Kannagi R (1996) J Gastroenterol 31: 299–301.PubMedCrossRefGoogle Scholar
  31. 31.
    Kawakami-Kimura N, Narita T, Ohmori K, Yoneda T, Matsumoto K, Nakamura T, Kannagi R (1996) Br J Cancer 75: 47–53.Google Scholar
  32. 32.
    Sato M, Narita T, Kawakami-Kimura N, Higashiyama S, Taniguchi N, Akiyama S, Hashimoto T, Manabe T, Kannagi R (1996) Cancer Lett 102: 183–191.CrossRefGoogle Scholar
  33. 33.
    Narita T, Kawakami-Kimura N, Sato M, Matsuura N, Higashiyama S, Taniguchi N, Kannagi R (1996) Oncology (in press).Google Scholar
  34. 34.
    Aruffo A, Dietsch MT, Wan H, Hellstrom KE, Hellstrom I (1992) Proc Natl Acad Sci USA 89: 2292–96.PubMedCrossRefGoogle Scholar
  35. 35.
    Hakomori S (1994) Biochem Biophys Res Commun 203: 1605–13.PubMedCrossRefGoogle Scholar
  36. 36.
    Mannori G, Crottet P, Cecconi O, Hanasaki K, Aruffo A, Nelson RM, Varki A, Bevilacqua MP (1995) Cancer Res 55: 4425–31.PubMedGoogle Scholar
  37. 37.
    Handa K, White T, Ito K, Fang H, Wang S-S, Hakomori S-I (1995) Int J Oncol 6: 773–81.Google Scholar
  38. 38.
    Moore KL, Eaton SF, Lyons DE, Lichenstein HS, Cummings RD, McEver RP (1994) J Biol Chem 269: 23318–27.PubMedGoogle Scholar
  39. 39.
    Asa D, Raycroft L, Ma L, Aeed PA, Kaytes PS, Elhammer AP, Geng J-G (1995) J Biol Chem 270: 11662–70.PubMedCrossRefGoogle Scholar
  40. 40.
    Moore KL, Patel KD, Bruehl RE, Fugang L, Johnson DA, Lichenstein HS, Cummings RD, Bainton DF, McEver RP (1995) J Cell Biol 128: 661–71.PubMedCrossRefGoogle Scholar
  41. 41.
    Ma L, Raycroft L, Asa D, Anderson DC, Geng J-G (1994) J Biol Chem 269: 27739–46.PubMedGoogle Scholar
  42. 42.
    Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (1990) Genes Devel 4, 1288–303.PubMedGoogle Scholar
  43. 43.
    Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi Rosso G, Lobb R (1990) Cell 63: 1349–56.PubMedCrossRefGoogle Scholar
  44. 44.
    Lowe JB, Kukowska-Latallo JF, Nair RP, Larsen RD, Marks RM, Macher BA, Kelly RJ, Ernst LK (1991) J Biol Chem 266: 17467–77.PubMedGoogle Scholar
  45. 45.
    Koszdin KL, Bowen BR (1992) Biochem Biophys Res Commun 187: 152–57.PubMedCrossRefGoogle Scholar
  46. 46.
    Weston BW, Nair RP, Larsen RD, Lowe JB (1992) J Biol Chem 267: 4152–60.PubMedGoogle Scholar
  47. 47.
    Weston BW, Smith PL, Kelly RJ, Lowe JB (1992) J Biol Chem 267: 24575–84.PubMedGoogle Scholar
  48. 48.
    Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (1994) J Biol Chem 269: 14730–37.PubMedGoogle Scholar
  49. 49.
    Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (1994) J Biol Chem 269: 16789–94.PubMedGoogle Scholar
  50. 50.
    Yago K, Zenita K, Ginya H, Sawada M, Ohmori K, Okuma M, Kannagi R, Lowe JB (1993) Cancer Res 53: 5559–65.PubMedGoogle Scholar
  51. 51.
    Dall'Olio F, Chiricolo M, Lollini P, Lau JTY (1995) Biochem Biophys Res Commun 211: 554–61.PubMedCrossRefGoogle Scholar
  52. 52.
    Majuri ML, Niemelaä R, Tiisala S, Renkonen O, Renkonen R (1995) Int J Cancer 63: 551–59.PubMedGoogle Scholar
  53. 53.
    Ho H, Hiraiwa N, Sawada-Kasugai M, Akamatsu S, Tachikawa T, Kasai Y, Akiyama S, Ho K, Takagi H, Kannagi R (1997) Int J Cancer (in press).Google Scholar
  54. 54.
    Dohi T, Hashiguchi M, Yamamoto S, Morita H, Oshima M (1994) Cancer 73: 1552–61.PubMedCrossRefGoogle Scholar
  55. 55.
    Akamatsu S, Yazawa S, Tachikawa T, Furuta T, Nakamura J, Asao T, Nagamachi Y (1996) Cancer 77Suppl: 1694–1700.PubMedGoogle Scholar
  56. 56.
    Kemmner W, Krueck D, Schlag P (1994) Clin Exp Metastasis 12: 245–54.PubMedCrossRefGoogle Scholar

Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • Reiji Kannagi
    • 1
  1. 1.Molecular PathologyAichi Cancer CenterNagoyaJapan

Personalised recommendations