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Biotechnology Letters

, Volume 19, Issue 10, pp 1043–1047 | Cite as

Model-based design of biochemical processes: simulation studies and experimental tests

  • V. Galvanauskas
  • R. Simutis
  • A. Lübbert
Article

Abstract

A simple design procedure is proposed that can be used to enhance the performance of a biological cultivation process. The model-supported method starts with a simple model. This is used to design first experiment, i.e., to calculate such a control profile that improves the process performance. The results of the experiment are then used to update the model and subsequently the control profiles. The procedure was first tested at simulated Saccharomyces cerevisiae and Penicillum chrysogenum cultivation processes and then practically applied to optimize an E.coli cultivation.

Keywords

Organic Chemistry Simple Model Simulation Study Saccharomyces Cerevisiae Saccharomyces 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • V. Galvanauskas
    • 1
  • R. Simutis
    • 1
  • A. Lübbert
    • 1
  1. 1.Institut für Bioverfahrenstechnik und ReaktionstechnikMartin-Luther-Universität Halle-WittenbergGermany

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