Model-based design of biochemical processes: simulation studies and experimental tests
- 51 Downloads
A simple design procedure is proposed that can be used to enhance the performance of a biological cultivation process. The model-supported method starts with a simple model. This is used to design first experiment, i.e., to calculate such a control profile that improves the process performance. The results of the experiment are then used to update the model and subsequently the control profiles. The procedure was first tested at simulated Saccharomyces cerevisiae and Penicillum chrysogenum cultivation processes and then practically applied to optimize an E.coli cultivation.
KeywordsOrganic Chemistry Simple Model Simulation Study Saccharomyces Cerevisiae Saccharomyces
Unable to display preview. Download preview PDF.
- Fukuda, H, Shiotani, T, Okada, W and Morikawa, H (1978). Ferment. Technol. 56: 361–368Google Scholar
- Galvanauskas, V, Simutis, R, Volk, N and Lübbert, A (1997). Bioprocess Engineering, in pressGoogle Scholar
- Glassey, J, Montague, GA, Ward, AC and Kara, BV (1994). Biotechnol. Bioeng. 44: 397–405Google Scholar
- Menezes, JC, Alves, SS, Lemos, JM and Feyo de Azevedo, S (1994). J. Chem. Tech. Biotechnol. 61:123–138Google Scholar
- Montgomery, DC (1991). Design and analysis of experiments, New York: WileyGoogle Scholar
- Simutis, R and Lübbert, A (1997a). Advances in modeling for bioprocess supervision and control. In: Bioseparation and Bioprocessing, G Subramanian, ed, in press, Weinheim: VCHGoogle Scholar
- Simutis, R and Lübbert, A (1997b). J. Biotechnology 52: 245–256Google Scholar