Molecular and Cellular Biochemistry

, Volume 222, Issue 1–2, pp 41–47

In vivo reduction of chromium (VI) and its related free radical generation


DOI: 10.1023/A:1017994720562

Cite this article as:
Liu, K. & Shi, X. Mol Cell Biochem (2001) 222: 41. doi:10.1023/A:1017994720562


Chromium (VI) compounds are widely recognized as human carcinogens. Extensive studies in vitro and in model systems indicate that the reactive intermediate, Cr (V), generated by cellular reduction of Cr (VI), is likely the candidate for the ultimate carcinogenic form of chromium compounds. Here we review our current understanding of the in vivo reduction of Cr (VI) and its related free radical generation. Our results demonstrate that Cr (V) is indeed generated from the reduction of Cr (VI) in vivo, and that Cr (V) thus formed can mediate the generation of free radicals. Cr (V) and its related free radicals are very likely to be involved in the mechanism of Cr (VI)‐induced toxicity and carcinogenesis. These studies also illustrate that in vivo EPR spectroscopy and magnetic resonance imaging can be very useful and powerful tools for studying paramagnetic metal ions in chemical and biochemical reactions occurring in intact animals.

EPR chromium free radical MRI reactive oxygen species 

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  1. 1.College of PharmacyUniversity of New MexicoAlbuquerqueUSA
  2. 2.National Institute for Occupational Safety and HealthMorgantownUSA

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