Digestive Diseases and Sciences

, Volume 47, Issue 3, pp 614–618 | Cite as

CASE REPORT: Acute Pancreatitis After Single-Dose Exposure to Propofol: A Case Report and Review of Literature

  • Qaiser Jawaid
  • Michael E. Presti
  • Brent A. Neuschwander-Tetri
  • Frank R. Burton
Article
acute pancreatitis hypertriglyceridemia propofol drug-induced pancreatitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    Mallory A, Kern F, Jr: Drug-induced pancreatitis: A critical review. Gastroenterology 78:813–820, 1980Google Scholar
  2. 2.
    Steinberg W, Tenner S: Acute pancreatitis. N Engl J Med 330:1198–1210, 1994Google Scholar
  3. 3.
    Lankisch PG, Droge M, Gottesleben F: Drug induced acute pancreatitis: Incidence and severity. Gut 37:565–567, 1995Google Scholar
  4. 4.
    Wingfield TW: Pancreatitis after propofol administration: Is there a relationship? Anesthesiology 84:236–237, 1996Google Scholar
  5. 5.
    Leisure GS, O'Flaherty J, Green L, Jones DR: Propofol and postoperative pancreatitis. Anesthesiology 84:224–227, 1996Google Scholar
  6. 6.
    Goodale D, Suljaga-Petchel K: Pancreatitis after propofol administration: Is there a relationship? Anesthesiology 84:236–237, 1996Google Scholar
  7. 7.
    Metkus AP, Trabulsy PP, Schlobohm RS, Hickey MS: A fire-fighter with pancreatitis. Lancet 348:1702, 1996Google Scholar
  8. 8.
    Possidente CJ, Rogers FB, Osler TM, Smith TA: Elevated pancreatic enzymes after extended propofol therapy. Pharmacotherapy 18:653–655, 1998Google Scholar
  9. 9.
    Kumar AN, Schwartz DE, Lim KG: Propofol-induced pancreatitis: Recurrence of pancreatitis after rechallenge. Chest 115:1198–1199, 1999Google Scholar
  10. 10.
    McArthur KE: Review article: Drug-induced pancreatitis. Aliment Pharmacol Ther 10:23–38, 1996Google Scholar
  11. 11.
    Eland IA, van Puijenbroek EP, Sturkenboom MJ, Wilson JH, Stricker BH: Drug-associated acute pancreatitis: twenty-one years of spontaneous reporting in The Netherlands. Am J Gastroenterol 94:2417–2422, 1999Google Scholar
  12. 12.
    Prys-Roberts C: Continuous intravenous infusion. Mt Sinai J Med 50:295–299, 1983Google Scholar
  13. 13.
    Fahy LT, van Mourik GA, Utting JE: A comparison of the induction characteristics of thiopentone and propofol (2,6-diisopropyl phenol). Anaesthesia 40:939–944, 1985Google Scholar
  14. 14.
    Coates DP, Prys-Roberts C, Spelina KR, Monk CR, Norley I: Propofol (Diprivan) by intravenous infusion with nitrous oxide: Dose requirements and haemodynamic effects. Postgrad Med J 61:76–79, 1985Google Scholar
  15. 15.
    Cockshott ID, Briggs LP, Douglas EJ, White M: Pharmacokinetics of propofol in female patients. Studies using single bolus injections. Br J Anaesth 59:1103–1110, 1987Google Scholar
  16. 16.
    Price ML, Walmsley A, Swaine C, Ponte J: Comparison of a total intravenous anaesthetic technique using a propofol infusion, with an inhalational technique using enflurane for day case surgery. Anaesthesia 43:84–87, 1988Google Scholar
  17. 17.
    Mackenzie N, Grant IS: Comparison of propofol with methohexitone in the provision of anaesthesia for surgery under regional blockade. Br J Anaesth 57:1167–1172, 1985Google Scholar
  18. 18.
    Newman LH, McDonald JC, Wallace PG, Ledingham IM: Propofol infusion for sedation in intensive care. Anaesthesia 42:929–937, 1987Google Scholar
  19. 19.
    Grounds RM, Maxwell DL, Taylor MB, Aber V, Royston D: Acute ventilatory changes during i.v. induction of anaesthesia with thiopentone or propofol in man. Studies using inductance plethysmography. Br J Anaesth 59:1098–1102, 1987Google Scholar
  20. 20.
    Snellen F, Lauwers P, Demeyere R, Byttebier G, Van Aken H: The use of midazolam versus propofol for short-term sedation following coronary artery bypass grafting. Intensive Care Med 16:312–316, 1990Google Scholar
  21. 21.
    Carrasco G, Molina R, Costa J, Soler JM, Cabre L: Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients. A cost-benefit analysis. Chest 103:557–564, 1993Google Scholar
  22. 22.
    Barr J: Propofol: A new drug for sedation in the intensive care unit. Int Anesthesiol Clin 33:131–154, 1995Google Scholar
  23. 23.
    Marinella MA: Propofol for sedation in the intensive care unit: Essentials for the clinician. Respir Med 91:505–510, 1997Google Scholar
  24. 24.
    Weinbroum AA, Halpern P, Rudick V, Sorkine P, Freedman M, Geller E: Midazolam versus propofol for long-term sedation in the ICU: A randomized prospective comparison. Intensive Care Med 23:1258–1263, 1997Google Scholar
  25. 25.
    Wood PR, Browne GP, Pugh S: Propofol infusion for the treatment of status epilepticus. Lancet 1:480–481, 1988Google Scholar
  26. 26.
    Lowson S, Gent JP, Goodchild CS: Anticonvulsant properties of propofol and thiopentone: Comparison using two tests in laboratory mice. Br J Anaesth 64:59–63, 1990Google Scholar
  27. 27.
    De Riu PL, Petruzzi V, Testa C, Mulas M, Melis F, Caria MA, Mameli O: Propofol anticonvulsant activity in experimental epileptic status. Br J Anaesth 69:177–181, 1992Google Scholar
  28. 28.
    Laycock GJ: Opisthotonos and propofol: A possible association. Anaesthesia 43:257, 1988Google Scholar
  29. 29.
    Paech MJ, Storey JM: Propofol and seizures. Anaesth Intensive Care 18:585, 1990Google Scholar
  30. 30.
    Borgeat A, Wilder-Smith OH, Saiah M, Rifat K: Subhypnotic doses of propofol possess direct antiemetic properties. Anesth Analg 74:539–541, 1992Google Scholar
  31. 31.
    Grattidge P: Patient-controlled sedation using propofol in day surgery. Anaesthesia 47:683–685, 1992Google Scholar
  32. 32.
    Ferrari LR, Donlon JV: A comparison of propofol, midazolam, and methohexital for sedation during retrobulbar and peribulbar block. J Clin Anesth 4:93–96, 1992Google Scholar
  33. 33.
    Borgeat A, Wilder-Smith OH, Saiah M, Rifat K: Subhypnotic doses of propofol relieve pruritus induced by epidural and intrathecal morphine. Anesthesiology 76:510–512, 1992Google Scholar
  34. 34.
    Borgeat A, Wilder-Smith O, Mentha G, Huber O: Propofol and cholestatic pruritus. Am J Gastroenterol 87:672–674, 1992Google Scholar
  35. 35.
    Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS: Pharmacokinetics of propofol (diprivan) in elderly patients. Br J Anaesth 60:146–150, 1988Google Scholar
  36. 36.
    Fortson MR, Freedman SN, Webster PD 3rd: Clinical assessment of hyperlipidemic pancreatitis. Am J Gastroenterol 90:2134–2139, 1995Google Scholar
  37. 37.
    Toskes PP: Hyperlipidemic pancreatitis. Gastroenterol Clin North Am 19:783–791, 1990Google Scholar
  38. 38.
    Nakashima Y, Howard JM: Drug-induced acute pancreatitis. Surg Gynecol Obstet 145:105–109, 1977Google Scholar
  39. 39.
    Parker WA: Estrogen-induced pancreatitis. Clin Pharm 2:75–79, 1983Google Scholar
  40. 40.
    Stone NJ: Estrogen-induced pancreatitis: A caveat worth remembering. J Lab Clin Med 123:18–19, 1994Google Scholar
  41. 41.
    Stone NJ: Secondary causes of hyperlipidemia. Med Clin North Am 78:117–141, 1994Google Scholar
  42. 42.
    Glueck CJ, Lang J, Hamer T, Tracy T: Severe hypertriglyceridemia and pancreatitis when estrogen replacement therapy is given to hypertriglyceridemic women. J Lab Clin Med 123:59–64, 1994Google Scholar
  43. 43.
    Isley WL, Oki J: Estrogen-induced pancreatitis after discontinuation of concomitant medroxyprogesterone therapy. Am J Med 102:416–417, 1997Google Scholar
  44. 44.
    Flynn WJ, Freeman PG, Wickboldt LG: Pancreatitis associated with isotretinoin-induced hypertriglyceridemia. Ann Intern Med 107:63, 1987Google Scholar
  45. 45.
    Noseworthy J, Colodny AH, Eraklis AJ: Pancreatitis and intravenous fat: an association in patients with inflammatory bowel disease. J Pediatr Surg 18:269–272, 1983Google Scholar
  46. 46.
    Lashner B, Kirsner J, Hanauer S: Acute pancreatitis associated with high-concentration lipid emulsion during total parenteral nutrition therapy for Crohn's disease. Gastroenterology 90:1039–1041, 1986Google Scholar
  47. 47.
    Leibowitz AB, O'sullivan P, Iberti TJ: Intravenous fat emulsions and the pancreas: A review. Mt Sinai J Med 59:38–42, 1992Google Scholar
  48. 48.
    Domínguez-Muñoz JE, Jünemann F, Malfertheiner P: Hyperlipidemia in acute pancreatitis. Cause or epiphenomenon? Int J Pancreatol 18:101–106, 1995Google Scholar
  49. 49.
    Gottardis M, Khunl-Brady KS, Koller W, Sigl G, Hackl JM: Effect of prolonged sedation with propofol on serum triglyceride and cholesterol concentrations. Br J Anaesth 62:393–396, 1989Google Scholar
  50. 50.
    Eddleston JM, Shelly MP: The effect on serum lipid concentrations of a prolonged infusion of propofol—hypertriglyceridaemia associated with propofol administration. Intensive Care Med 17:424–426, 1991Google Scholar
  51. 51.
    Lowrey TS, Dunlap AW, Brown RO, Dickerson RN, Kudsk KA: Pharmacologic influence on nutrition support therapy: Use of propofol in a patient receiving combined enteral and parenteral nutrition support. Nutri Clin Pract 11:147–149, 1996Google Scholar
  52. 52.
    Mateu J, Barrachina F: Hypertriglyceridaemia associated with propofol sedation in critically ill patients. Intensive Care Med 22:834–835, 1996Google Scholar
  53. 53.
    Barrientos-Vega R, Mar Sanchez-Soria M, Morales-Garcia C, Robas-Gomez A, Cuena-Boy R, Ayensa-Rincon A: Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs. Crit Care Med 25:33–40, 1997Google Scholar
  54. 54.
    Miller LJ, Wiles-Pfeifler R: Propofol for the long-term sedation of a critically ill patient. Am J Crit Care 7:73–76, 1998Google Scholar
  55. 55.
    Donmez A, Arslan G, Pirat A, Demirhan B: Is pancreatitis a complication of propofol infusion? Eur J Anaesthesiol 16:367–370, 1999Google Scholar
  56. 56.
    Donmez A, Sener M, Candan S, Arslan G: Can we blame propofol for pancreatitis? Pharmacotherapy 19:1181–1182, 1999Google Scholar
  57. 57.
    White M, Morgan A, Hopton D: Postoperative Pancreatitis. Am J Surg 120:132–137, 1970Google Scholar
  58. 58.
    Begley CG, Roberts-Thomson IC: Spontaneous improvement in pancreatic function in chronic pancreatitis. Dig Dis Sci 30:1117–1120, 1985Google Scholar
  59. 59.
    Holtzer JD, Hulst SG: Confirmation of postcholecystectomy biliary dyskinesia by elevation of serum transaminases (GOT and GPT) after injection of morphine? Acta Med Scand 194:221–224, 1973Google Scholar
  60. 60.
    Hastier P, Longo F, Buckley M, Chichmanian RM, Delmont JP: Pancreatitis induced by codeine: A case report with positive rechallenge. Gut 41:705–706, 1997Google Scholar
  61. 61.
    Bragg L, Thompson J, Burnett D, Hodgson P, Rikkers L: Increased incidence of pancreas-related complications in patients with post-operative pancreatitis. Am J Surg 150:694–697, 1985Google Scholar
  62. 62.
    Lefor A, Vuocolo P, Parker FJ, Sillin L: Pancreatic complications following cardiopulmonary bypass: Factors influencing mortality. Arch Surg 127:1225–1231, 1992Google Scholar
  63. 63.
    Bird H, Brim V: Propofol and postoperative pancreatitis. Anaesthesia 55:506–507, 2000Google Scholar

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Qaiser Jawaid
    • 1
  • Michael E. Presti
    • 1
  • Brent A. Neuschwander-Tetri
    • 1
  • Frank R. Burton
    • 1
  1. 1.Division of Gastroenterology and HepatologySaint Louis University School of MedicineSaint LouisUSA

Personalised recommendations