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Molecular and Cellular Biochemistry

, Volume 222, Issue 1–2, pp 3–9 | Cite as

Molecular mechanisms of metal toxicity and carcinogenesis

  • Suwei Wang
  • Xianglin ShiEmail author
Article

Abstract

Many metals and metal-containing compounds have been identified to be potent mutagens and carcinogens. Recently, a new sub-discipline of molecular toxicology and carcinogenesis has been developed. The combination of newly developed molecular techniques and free radical approach makes it possible to insightfully examine metal-induced carcinogenesis in precise molecular terms so that intricate biological interrelationships can be elucidated. In consideration of the increased amount of new findings deciphered by utilizing these new methods, the 1st Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held. In this conference, more than 50 scientists from nine countries presented their novel discoveries concerning metal-induced carcinogenesis, delineated molecular mechanism of metal carcinogenesis, and proposed novel therapeutic intervention and prevention strategies. This article reviewes some of the state-of-the-art information presented at the meeting regarding the molecular mechanisms of metal cytotoxicity and carcinogenesis.

ROS cell growth regulation transcription factor signal transduction cytotoxicity and carcinogenesis 

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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  1. 1.Pathology and Physiology Research Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantown
  2. 2.Department of Basic Pharmaceutical SciencesWest Virginia UniversityMorgantownUSA

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