Validation of a Flow-Through Diffusion Cell for Use in Transdermal Research
- 255 Downloads
A flow-through finite-dose diffusion cell has been designed for use in transdermal drug delivery research. The diffusion cell consists of an upper donor chamber and a lower receiver compartment through which a continuous supply of fresh solvent flows. The flow is directed to an automatic fraction collector. To validate the flow-through cell, its performance was compared directly against that of a conventional single-reservoir Franz cell. Homologous alkyl p-aminobenzoates were diffused through dimethylpolysiloxane membranes, and permeability coefficients increased with increasing chain length, reaching a plateau at the butyrate ester for both types of cells. This behavior suggests a shift from membrane-controlled diffusion to boundary layer control. Permeation of the butyrate and valerate compounds was significantly faster when the flow-through cell was used, suggesting that better mixing is obtained through the flow-through cell design. Considering the advantages offered in terms of time and labor saved through its use, the flow-through cell with automatic fraction collector appears to be a viable alternative to the conventional Franz cell.
Unable to display preview. Download preview PDF.
- 1.R. L. Bronaugh and R. F. Stewart. J. Pharm. Sci. 74:64–67 (1985).Google Scholar
- 2.A. I. Vogel. A Textbook of Practical Organic Chemistry, John Wiley and Sons, New York, 1962, p. 1001.Google Scholar
- 3.S. H. Yalkowski, G. L. Flynn, and T. G. Slunick. J. Pharm. Sci. 61:852–857 (1972).Google Scholar
- 4.A. C. Shah and K. G. Nelson. J. Pharm. Sci. 69:210–212 (1980).Google Scholar
- 5.G. L. Flynn and S. H. Yalkowski. J. Pharm. Sci. 61:838–851 (1972).Google Scholar
- 6.B. W. Barry. Dermatological Formulations: Percutaneous Absorption, Dekker, New York, 1983, p. 242.Google Scholar
- 7.R. H. Guy, A. H. Guy, H. I. Maibach, and V. P. Shah. Pharm Res. 3:253–262 (1986).Google Scholar