Pharmaceutical Research

, Volume 4, Issue 4, pp 337–341 | Cite as

Validation of a Flow-Through Diffusion Cell for Use in Transdermal Research

  • William J. Addicks
  • Gordon L. Flynn
  • Norman Weiner
Article

Abstract

A flow-through finite-dose diffusion cell has been designed for use in transdermal drug delivery research. The diffusion cell consists of an upper donor chamber and a lower receiver compartment through which a continuous supply of fresh solvent flows. The flow is directed to an automatic fraction collector. To validate the flow-through cell, its performance was compared directly against that of a conventional single-reservoir Franz cell. Homologous alkyl p-aminobenzoates were diffused through dimethylpolysiloxane membranes, and permeability coefficients increased with increasing chain length, reaching a plateau at the butyrate ester for both types of cells. This behavior suggests a shift from membrane-controlled diffusion to boundary layer control. Permeation of the butyrate and valerate compounds was significantly faster when the flow-through cell was used, suggesting that better mixing is obtained through the flow-through cell design. Considering the advantages offered in terms of time and labor saved through its use, the flow-through cell with automatic fraction collector appears to be a viable alternative to the conventional Franz cell.

transdermal diffusion cells flow-through Franz cell 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

REFERENCES

  1. 1.
    R. L. Bronaugh and R. F. Stewart. J. Pharm. Sci. 74:64–67 (1985).Google Scholar
  2. 2.
    A. I. Vogel. A Textbook of Practical Organic Chemistry, John Wiley and Sons, New York, 1962, p. 1001.Google Scholar
  3. 3.
    S. H. Yalkowski, G. L. Flynn, and T. G. Slunick. J. Pharm. Sci. 61:852–857 (1972).Google Scholar
  4. 4.
    A. C. Shah and K. G. Nelson. J. Pharm. Sci. 69:210–212 (1980).Google Scholar
  5. 5.
    G. L. Flynn and S. H. Yalkowski. J. Pharm. Sci. 61:838–851 (1972).Google Scholar
  6. 6.
    B. W. Barry. Dermatological Formulations: Percutaneous Absorption, Dekker, New York, 1983, p. 242.Google Scholar
  7. 7.
    R. H. Guy, A. H. Guy, H. I. Maibach, and V. P. Shah. Pharm Res. 3:253–262 (1986).Google Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • William J. Addicks
    • 1
  • Gordon L. Flynn
  • Norman Weiner
  1. 1.College of PharmacyUniversity of MichiganAnn Arbor

Personalised recommendations