The Histochemical Journal

, Volume 33, Issue 11–12, pp 685–694 | Cite as

Corticotropin-releasing Hormone-like Immunoreactivity in the Brain of the Snake Bothrops Jararaca

  • P.F. Silveira
  • M.C. Breno
  • G. Puorto
  • M.P. Martín del Río
  • J.M. Mancera


The distribution of corticotropin-releasing hormone in the brain of the snake Bothrops jararaca was studied immunohistochemically. Immunoreactive neurons were detected in telencephalic, diencephalic and mesencephalic areas such as dorsal cortex, subfornical organ, paraventricular nucleus, recessus infundibular nucleus, nucleus of the oculomotor nerve and nucleus of the trigeminal nerve. Immunoreactive fibres ran along the hypothalamo-hypophysial tract to end in the outer layer of the median eminence and the neural lobe of the hypophysis. In general, immunoreactive fibres occurred in the same places of immunoreactive neurons. In addition, immunoreactive fibres were observed in the septum, amygdala, lamina terminalis, supraoptic nucleus, nucleus of the paraventricular organ, ventromedial hypothalamic nucleus and interpeduncular nucleus. These results indicate that, as for other vertebrates, corticotropin-releasing hormone in B. jararaca brain, besides being a releasing hormone, may also act as a central neurotransmitter and/or neuromodulator.


Paraventricular Nucleus Median Eminence Hypothalamic Nucleus Oculomotor Nerve Immunoreactive Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • P.F. Silveira
    • 1
    • 2
  • M.C. Breno
    • 2
  • G. Puorto
    • 3
  • M.P. Martín del Río
    • 1
  • J.M. Mancera
    • 4
  1. 1.Department of Animal Biology, Faculty of Marine ScienceUniversity of CádizPuerto Real, CádizSpain
  2. 2.Laboratory of PharmacologyInstituto ButantanSão PauloBrazil
  3. 3.Biological MuseumInstituto ButantanSão PauloBrazil
  4. 4.Department of Animal Biology, Faculty of Marine ScienceUniversity of CádizPuerto Real, CádizSpain

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