Pharmaceutical Research

, Volume 3, Issue 3, pp 123–131

Comparison of Canine and Human Gastrointestinal Physiology

  • Jennifer B. Dressman
Article

DOI: 10.1023/A:1016353705970

Cite this article as:
Dressman, J.B. Pharm Res (1986) 3: 123. doi:10.1023/A:1016353705970

Abstract

In this review, the gross physiology of the gastrointestinal tract of dogs is compared with that of humans, particularly as it pertains to drug absorption and dosage-form performance. Gastrointestinal (GI) motility and pH are the main parameters considered. Although similar motility patterns and pH profiles prevail in the two species for the most part, there are some differences that could affect the time profile and extent of drug absorption. These include slower gastric emptying in the fed state, faster small intestine transit, and higher and more variable intestinal pH in dogs compared with humans. An attempt is made to identify drug and dosage-form properties that would lead to differences in drug absorption in the two species, e.g., drug physicochemical properties, dosage-form size, and pH dependency of dosage-form release characteristics.

drug absorption gastrointestinal tract, dogs gastrointestinal mobility and pH gastrointestinal drug absorption 

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Jennifer B. Dressman
    • 1
  1. 1.College of PharmacyThe University of MichiganAnn Arbor

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