Pharmaceutical Research

, Volume 3, Issue 6, pp 318–326 | Cite as

lontophoretic Devices for Drug Delivery

  • Praveen Tyle
Article

Abstract

Transdermal drug delivery of ionized drugs can be enhanced by iontophoresis. Drug in the ionic form, contained in some reservoir, can be “phoresed” through the skin with a small current across two electrodes, one above the reservoir and one at a distal skin location. Positive ions can be introduced from the positive pole, or negative ions from the negative pole. The design and development of iontophoretic devices are rather simple. Some of the principles of operation and the advantages/disadvantages and clinical implications associated with these devices are outlined in this review.

Iontophoresis Drug Delivery Devices Controlled Drug Delivery Transdermal Drug Delivery Electroosmosis Drug Delivery Devices 

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REFERENCES

  1. 1.
    H. A. Abramson and M. H. Gorin. J. Phys. Chem. 44:1094–1102 (1940).Google Scholar
  2. 2.
    S. Rothman. (ed.) In Physiology and Biochemistry of the Skin, University of Chicago Press, Chicago, 1954, p. 38.Google Scholar
  3. 3.
    S. Rothman. Hanbuch Normal. Pathol. Physiol. 4 (107):143–149 (1929).Google Scholar
  4. 4.
    H. Schaefer. In H. Schaefer, A. Zesch, and G. Stuttgen (eds.), Skin Permeability, Springer-Verlag, Boston, 1982, pp. 640–641.Google Scholar
  5. 5.
    D. Abramowitsch and B. Neoussikine. In Treatment by Ion Transfer, Grune & Stratton, New York, 1946, p. 87.Google Scholar
  6. 6.
    W. B. Shelly, J. C. McConahy, and E. N. Hesbacher. J. Invest. Dermatol. 15 (5):343–344 (1950).Google Scholar
  7. 7.
    D. M. Jenkinson and G. S. Walton. Vet. Rec. Jan. 5:8–12 (1974).Google Scholar
  8. 8.
    W. E. Rahm, W. F. Strother, J. F. Crump, and D. E. Parker. Ann. Otol. Rhinol. Laryngol. 71:116–123 (1962).Google Scholar
  9. 9.
    M. Comeau and R. Brummett. Laryngoscope 88:277–285 (1978).Google Scholar
  10. 10.
    A. S. Rapperport, D. L. Larson, D. F. Henges, J. B. Lynch, T. G. Blocker, and R. S. Lewis. Plastic Reconstruc. Surg. 36:547–552. (1965).Google Scholar
  11. 11.
    D. H. Kling and D. Sashin. Arch. Phys. Ther. X-Ray Radium 18:333–338 (1937).Google Scholar
  12. 12.
    J. Russo, Jr., A. G. Lipman, T. J. Cornstock, B. C. Page, and R. L. Stephan. Am. J. Hosp. Pharm. 37:843–847 (1980).Google Scholar
  13. 13.
    L. P. Gangarosa, N. H. Park, C. A. Wiggins, and J. M. Hill. J. Pharm. Exp. Ther. 212 (3):377–381 (1980).Google Scholar
  14. 14.
    S. LeDuc. Electric Ions and Their Use in Medicine, Rebman, London, 1908.Google Scholar
  15. 15.
    A. Strohl, J. Verne, J. C. Roucayrol, and P. F. Ceccaldi. C.R. Soc. Biol. 144:819–824 (1950).Google Scholar
  16. 16.
    L. von Sallmann. Am. J. Ophthal. 25:1292–1300 (1942).Google Scholar
  17. 17.
    P. R. Harris. J. Orthopaed. Sports Phys. Ther. 4 (2):109–112 (1982).Google Scholar
  18. 18.
    F. G. Delacerda. J. Orthopaed. Sports Phys. Ther. 4 (1):51–54 (1982).Google Scholar
  19. 19.
    S. S. Riar, R. C. Sawhney, J. Bardhan, P. Thomas, R. K. Jain, and A. K. Jain. Andrologia 14 (6):481–491 (1982).Google Scholar
  20. 20.
    L. P. Gangarosa, N. H. Park, B. C. Fong, D. F. Scott, and J. M. Hill. J. Pharm. Sci. 67 (10):1439–1443 (1978).Google Scholar
  21. 21.
    B. Kari. Diabetes 35 (2):217–221 (1986).Google Scholar
  22. 22.
    R. L. Stephen, T. J. Petelenz, and S. C. Jacobsen. Biomed. Acta 43 (5):553–558 (1984).Google Scholar
  23. 23.
    C. A. Webster. CRC Crit. Rev. Clin. Lab. Sci. 18 (14):313–338 (1983).Google Scholar
  24. 24.
    P. Tyle. In Proceedings of the Bio-Expo '86, The American Commercial & Industrial Conference & Exposition in Biotechnology, Butterworth, Stoneham, Mass., 1986, pp. 583–594.Google Scholar
  25. 25.
    R. H. De Jong. In M. B. Ravin (ed.), Problems in Anesthesia, A Case Study Approach, Little, Brown, Boston, 1981, pp. 129–140.Google Scholar
  26. 26.
    T. Rosendal. Acta Physiol. Scand. 5:130–151 (1942–1943).Google Scholar
  27. 27.
    D. F. Echols, C. H. Norris, and H. G. Tabb. Arch. Otolaryngol. 101:418–421 (1975).Google Scholar
  28. 28.
    M. Comeau and J. Vernon. Arch Otolaryngol. 98:114–120 (1973).Google Scholar
  29. 29.
    R. Harris. In S. Licht (ed.), Therapeutic Electricity and Ultraviolet Radiation, Waverly Press, Baltimore, 1967, pp. 156–178.Google Scholar
  30. 30.
    L. P. Gangarosa, H. W. Merchant, N. H. Park, and J. M. Hill. Methods Find. Exp. Clin. Pharmacol. 1:105–109 (1979).Google Scholar
  31. 31.
    H. A. Abramson. J. Allergy 12:169–175 (1941).Google Scholar
  32. 32.
    A. Globus. In R. F. Thompson and M. M. Patterson (eds.), Bioelectric Recording Techniques, Part A: Cellular Processes and Brain Potentials, Academic Press, London, New York, 1973, pp. 23–38.Google Scholar
  33. 33.
    T. Masada, U. Rohr, W. I. Higuchi, J. Fox, C. Behl, W. Malick, A. H. Goldberg, S. Pons. In 39th National Meeting of the Academy of Pharmaceutical Sciences Abstracts, Minneapolis, Minnesota, 1985, Vol. 15 (2), p. 73.Google Scholar
  34. 34.
    R. R. Burnette and D. Marerro. J. Pharm. Sci. 75:738–743 (1986).Google Scholar
  35. 35.
    E. P. O'Malley and Y. T. Oester. Arch. Phys. Med. Rehab. 36:310–316 (1955).Google Scholar
  36. 36.
    H. A. Abramson and A. Alley. Arch. Phys. Ther. 18:327 (1937).Google Scholar
  37. 37.
    K. Harpuder. Arch. Phys. Ther. X-Ray Radium 18:221–225 (1937).Google Scholar
  38. 38.
    O. Siddiqui, M. S. Roberts, and A. Z. Polack, J. Pharm. Pharmacol. 37:732–735 (1985).Google Scholar
  39. 39.
    B. Jankelson. U.S. Patent No. 3,746,004 (1973).Google Scholar
  40. 40.
    W. J. Shriber (ed). In A Manual of Electrotherapy, 4th ed., Lea & Febiger, Philadelphia, 1975, pp. 123, 131.Google Scholar
  41. 41.
    N. H. Bellatone, S. Rim, M. L. Francoeur, and B. Rasadi. Int. J. Pharmaceutics. 30:63–72 (1986).Google Scholar
  42. 42.
    T. Suchi. Jap. J. Physiol. 5:75–80 (1955).Google Scholar
  43. 43.
    R. Tapper. J. Clin. Eng. 8 (3):253–259 (1983).Google Scholar
  44. 44.
    R. Tapper. U.S. Patent No. 4,164,226 (1979).Google Scholar
  45. 45.
    R. Tapper. U.S. Patent No. 4,301,794 (1981).Google Scholar
  46. 46.
    Technical Insights, Inc. Drug Delivery Systems: A Technology Survey, Chap. 7, pp. 154–162.Google Scholar
  47. 47.
    W. J. Jochem, A. R. Light, and D. Smith. J. Neurosci. Methods 3:261–269 (1981).Google Scholar
  48. 48.
    T. Ishikawa, S. Kuriyama, Y. Takaesu, H. Furuishi, Y. Okuzaki, S. Motomura, and Y. Musha. U.S. Patent No. 4,149,533 (1979).Google Scholar
  49. 49.
    R. Teitelman. Forbes 135 (3):148–149 (1985).Google Scholar
  50. 50.
    Federal Register, August 28, 1979, 44 (168), 50520–50523; November 3, 1983, 48(227), 53052; Code of Federal Regulations, 890.5525, 1985, p. 271.Google Scholar
  51. 51.
    A. B. Coyer. Ann. Phys. Med. 2:16 (1954).Google Scholar
  52. 52.
    L. E. Bertolucci. J. Orthopaed. Sports Phys. Ther. 4 (2):103–108 (1982).Google Scholar
  53. 53.
    D. C. Boone. Phys. Ther. 49 (2):139–145 (1969).Google Scholar
  54. 54.
    B. S. Kwon, L. P. Gangarosa, N. H. Park, D. S. Hull, E. Fineberg, C. Wiggins, and J. M. Hill. Invest. Ophthalmol. Vis. Sci. 18 (9):984–988 (1979).Google Scholar
  55. 55.
    T. Petelenz, I. Axenti, T. J. Petelenz, J. Iwinski, and S. Dubel. J. Clin. Pharmacol. Ther. Toxicol. 22 (3):152–155 (1984).Google Scholar
  56. 56.
    J. M. Hill, L. P. Gangarosa, and N. H. Park. Ann N.Y. Acad. Sci. 284:604–612 (1977).Google Scholar
  57. 57.
    T. Cohn and S. Benson. Arch. Phys. Ther. X-Ray Radium 18:583–587 (1937).Google Scholar
  58. 58.
    L. Martin and G. O. Eaton. Arch. Phys. Ther. X-Ray Radium 18:226–237 (1937).Google Scholar
  59. 59.
    A. J. Schleuing, R. Brummett, and M. Comeau. Trans. Am. Acad. Ophthal. Otol. 78:453–457 (1974).Google Scholar
  60. 60.
    L. R. Gangarosa, Sr. In Iontophoresis in Dental Practice, 1st ed., Quintessence, Chicago, 1983.Google Scholar
  61. 61.
    L. P. Gangarosa. Methods Find. Exp. Clin. Pharmacol. 3 (2):83–94 (1981).Google Scholar
  62. 62.
    S. B. Arvidsson, R. H. Ekroth, A. M. C. Hansby, A. H. Lindholm, and G. William-Olsson. Acta Anaesthesiol Scand 28:209–210 (1984).Google Scholar
  63. 63.
    L. P. Gangarosa, N. H. Park, and J. M. Hill. Proc. Soc. Exp. Biol. Med. 154:439–443 (1977).Google Scholar
  64. 64.
    L. P. Gangarosa, M. Haynes, S. Qureshi, M. M. Salim, A. Ozawa, K. Hayakawa, M. Ohkido, and P. E. Mahan. 3rd International Dental Congress on Modern Pain Control, Abstracts, 1982, p. 221.Google Scholar
  65. 65.
    L. P. Gangarosa and P. E. Mahon. Ear Nose Throat J. 61:30–41 (1982).Google Scholar
  66. 66.
    A. H. Gordon and M. V. Weinstein. Phys. Ther. 49 (8):869–870 (1969).Google Scholar
  67. 67.
    J. Kahn. Phys. Ther. 55 (40):476–477 (1975).Google Scholar
  68. 68.
    J. Kahn. Phys. Ther. 57 (6):658–659 (1977).Google Scholar
  69. 69.
    C. D. Weir. J. Laryngol. 81:1143–1150 (1967).Google Scholar
  70. 70.
    S. H. Rothfeld and W. Murray. J. Urol. 97:874–875 (1967).Google Scholar
  71. 71.
    J. E. Marchand and N. Hagino. Exp. Neurol. 78 (3):790–795 (1982).Google Scholar
  72. 72.
    M. V. Weinstein and A. H. Gordon. Phys. Ther. Rev. 38:96–98 (1958).Google Scholar
  73. 73.
    B. Csillik, E. Knyihar-Csillik, and A. Szucs. Neurosci. Lett. 31:87–90 (1982).Google Scholar
  74. 74.
    I. Ulrich. Schweiz Rundschav Med. 69:617–619 (1979).Google Scholar
  75. 75.
    D. Kostadinov, I. Topalov, and I. Kiranov. Kurortol. Fizioter 10 (1):20–22 (1973).Google Scholar
  76. 76.
    S. B. Sokolov, E. K. Sveshnikova, Y. A. Lavrentier, A. I. Pertsovsky, I. K. Ivanov, G. N. Panevskaya, and A. G. Zhuchkov. Vopr Kurortol. Fizioter Lech Fizkult 5:12–15 (1981).Google Scholar
  77. 77.
    A. N. Ostrokhovich and N. I. Strelkova. S. S. Horsanov Zhurnal Neuropathol. Psikhiat. 82:34–38 (1982).Google Scholar
  78. 78.
    A. Martin, J. Swarbrick, and A. Cammarata. In Physical Pharmacy, Lea & Febiger, Philadelphia, 1983, p. 428.Google Scholar
  79. 79.
    P. Tyle and S. G. Frank. In Proceedings of the Medical Device and In Vitro Diagnostic Manufacturing Conference, MD & DI Central, Cannon Communication, Santa Monica, Calif. 1985, p. 89.Google Scholar
  80. 80.
    H. H. Schilkret. J. Invest. Dermatol. 5:11–14 (1942).Google Scholar
  81. 81.
    J. W. Caudill, E. Romanowski, T. Araullo-Cruz, and Y. J. Gordon. Curr. Eye Res. 5 (1):41–45 (1986).Google Scholar
  82. 82.
    K. Okabe, H. Yamaguchi, Y. Kawai. J. Controlled Rel. 4:79–85 (1986).Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Praveen Tyle
    • 1
  1. 1.American Cyanamid CompanyPrinceton

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