Journal of Autism and Developmental Disorders

, Volume 32, Issue 4, pp 263–281 | Cite as

Asperger Syndrome: Tests of Right Hemisphere Functioning and Interhemispheric Communication

  • Helen L. Gunter
  • Mohammad Ghaziuddin
  • Hadyn D. EllisEmail author


The primary aim of this investigation was to assess to what extent Rourke's (1989, 1995) nonverbal learning disabilities syndrome (NLD) model resembles the pattern of assets and deficits seen in people with Asperger syndrome (AS). NLD can be characterized by a cluster of deficits primarily affecting nonverbal aspects of functioning, in the presence of proficiency in single word reading and a superior verbal memory. The neurological underpinnings of this syndrome may be dysfunction of white matter affecting right hemisphere functioning and interhemispheric communication. To explore this hypothesis, eight participants with AS (ages 10 to 41 years) were assessed in the following areas: the pragmatics of language and communication, verbal and visual memory, visual-spatial abilities, and bimanual motor skills. Results confirmed the close similarity in the neuropsychologic profiles of NLD and AS.

Asperger syndrome nonverbal learning disabilities right hemisphere dysfunction interhemisphere communication neuropsychological assessment 


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  1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
  2. Asperger, H. (1991). “Autistiche Psychopathen” im Kindesalter. In U. Frith (Ed. and Trans.) Autism and Asperger syndrome (pp. 37–92). Cambridge: Cambridge University Press. (Original work published in 1944)Google Scholar
  3. Baron-Cohen, S., & Hammer, J. (1997). Parents of children with Asperger syndrome: what is the cognitive phenotype? Journal of Cognitive Neuroscience, 9 548–554.Google Scholar
  4. Baron-Cohen, S., Ring, H. A., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. C. R. (1999). Social intelligence in the normal and autistic brain: an fMRI study. European Journal of Neuroscience, 11 1891–1898.Google Scholar
  5. Berthier, M. L., Starkstein, S. E., & Leiguarda, R. (1990). Developmental cortical anomalies in Asperger's syndrome: neuroradiological findings in two patients. Journal of Neuropsychiatry and Clinical Neurosciences, 2 197–201.Google Scholar
  6. Bogen, J. E. (1993). The callosal syndrome. In K. M. Heilman & E. Valenstein (Eds.), Clinical neurology. (pp. 337–408). Oxford: Oxford University Press.Google Scholar
  7. Bottini, G., Corcoran, R., Sterzi, R., Scarpa, P., Frackwaik, R. J. S., & Frith, C. D. (1994). The role of the right hemisphere in the interpretation of figurative aspects of language: a position emission tomography activation study. Brain, 117 1241–1253.Google Scholar
  8. Brizzolara, D., Ferretti, G., Brovedani, P., Casalini, C., & Sbrana, B. (1994). Is interhemispheric transfer time related to age? A developmental study. Behavioral Brain Research, 64 179–184.Google Scholar
  9. Brothers, L. (1990). The social brain: a project for integrating primate behaviour and neurophysiology in a new domain. Concepts in Neuroscience, 1 27–51.Google Scholar
  10. Brothers, L. (1997). Friday's footprint. New York: Oxford University Press.Google Scholar
  11. Bryan, K. L. (1989). The Right Hemisphere Language Battery. Kibworth, England: Far Communications.Google Scholar
  12. Cutting, J. (1990). The right cerebral hemisphere and psychiatric disorders. Oxford: Oxford University Press.Google Scholar
  13. Delis, D. C., Robertson, L. C., & Efron, R. (1986). Hemispheric specialization of memory for hierarchical stimuli. Neuropsychologia, 24, 205–214.Google Scholar
  14. Dunn, L. M., Dunn, L. M., Whetton, C., & Pintilie, D. (1982). theBritish Picture Vocabulary Scale. London: NFER-Nelson.Google Scholar
  15. Elhers, S., Nyden, A., Gillberg, C., Dahlgren Sandberg, A., Dahlgren, S., Hjelmquist, E., & Oden, A. (1997). Asperger syndrome, autism and attention disorders: a comparative study of cognitive profiles of 120 children. Journal of Child Psychology and Psychiatry, 38 207–217.Google Scholar
  16. Ellis, H. D., Ellis, D. M., Fraser, W. I., & Deb, S. (1994). A preliminary study of right hemisphere cognitive deficits and impaired social judgments among young people with Asperger syndrome. European Child and Adolescent Psychiatry, 3 255–266.Google Scholar
  17. Ellis, H. D., & Gunter, H. L. (1999) Asperger syndrome: a simple matter of white matter? Trends in Cognitive Sciences, 3(5), 192–200.Google Scholar
  18. Ellis, H. D., & Leafhead, K. M. (1996). Raymond: A study of an adult with Asperger syndrome. In P. W. Halligan & J. C. Marshall (Eds.), Methods in madness: Case studies in cognitive neuropsychiatry (pp. 79–92). Oxford: Psychology Press.Google Scholar
  19. Frith, U. (1989). Autism: Explaining the enigma. Oxford: Basil Blackwell.Google Scholar
  20. Frith, U. (1991). Autism and Asperger syndrome. Cambridge: Cambridge University Press.Google Scholar
  21. Ghaziuddin, M., Tsai, L., & Ghaziuddin, N. (1992). Brief report. A reappraisal of clumsiness as a diagnostic feature of Asperger syndrome. Journal of Autism and Developmental Disorders, 32, 651–655.Google Scholar
  22. Ghaziuddin M, Gerstein L (1996). Pedantic speaking style differentiates Asperger syndrome from high-functioning autism. Journal of Autism and Developmental Disorders, 26 585–595.Google Scholar
  23. Gillberg, C. (1991). Clinical and neurobiological aspects of Asperger's syndrome in six family studies. In U. Frith (Ed.), Autism and Asperger syndrome (pp. 122–146). Cambridge: Cambridge University Press.Google Scholar
  24. Gillberg, C. (1998). Asperger syndrome and high-functioning autism. British Journal of Psychiatry, 172 200–209.Google Scholar
  25. Goldberg, E., & Costa, L. D. (1981). Hemisphere differences in the acquisition and use of descriptive systems. Brain and Language, 14, 144–173.Google Scholar
  26. Green, L., Fein, D., Joy, S., & Waterhouse, L. (1995). Cognitive functioning in autism: an overview. In E. Schopler & G. B. Mesibov (Eds.), Learning and cognition (pp. 200–215). New York: Plenum Press.Google Scholar
  27. Hellige, J. B. (1993). Hemispheric asymmetry: What's right and what's left. Cambridge: Harvard University Press.Google Scholar
  28. Jolliffe, T., & Baron-Cohen, S. (1997). Are people with autism and Asperger syndrome faster than normal on the Embedded Figures Test? Journal of Child Psychology and Psychiatry, 38, 527–534.Google Scholar
  29. Jones, P. B., & Kerwin, R. W. (1990) Left temporal lobe damage in Asperger's syndrome: British Journal of Psychiatry, 156, 570–572.Google Scholar
  30. Klin, A., Volkmar, F. R., Sparrow, S. S., Cicchetti, D. V., & Rourke, B. P. (1995). Validity and neuropsychological characterization of Asperger syndrome: convergence with nonverbal learning disabilities syndrome. Journal of Child Psychology and Psychiatry, 37, 1127–1140.Google Scholar
  31. Kracke, I. (1994). Developmental prosopagnosia in Asperger's syndrome: presentation and discussion of an individual case. Developmental Medicine and Child Neurology, 36 873–886.Google Scholar
  32. Krug, D. A., Arick, J., & Almond, P. (1980). Behavior checklist foridentifying severely handicapped individuals with high levels of autistic behavior. Journal of Child Psychology and Psychiatry, 21, 221–229.Google Scholar
  33. Lezak, M. D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.Google Scholar
  34. Lincoln, A., Courchesne, E., Allen, M., Hanson., E. & Ene, M. (1998). In E. Schopler, E., Mesibov, G., & Kunce, L. J. Asperger syndrome or high-functioning austism? (pp. 145–160). New York: Plenum Press.Google Scholar
  35. Manoach, D. S., Sandson, T. A., & Weintraub, S. (1995). The developmental social-emotional processing disorder associated with right hemisphere abnormalities. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 8, 99–105.Google Scholar
  36. McKelvey, J. R., Lambert, R., Mottron, L., & Shevell, M. I. (1995). Right hemisphere dysfunction in Asperger's syndrome. Journal of Child Neurology, 10 310–314.Google Scholar
  37. Mottron, L., & Belleville, S. (1993). A study of perceptual analysis in a high-level autistic subject with exceptional graphic abilities. Brain and Cognition, 23 279–309.Google Scholar
  38. Myklebust, H. R. (1975) Nonverbal learning disabilities: assessment and intervention. In H. R. Myklebust(Ed.) Progress in learning disabilities: Vol. 3. (pp. 281–301). New York: Grune and Stratton.Google Scholar
  39. Nass, R., & Gutman, R. (1997). Boys with Asperger's disorder, exceptional verbal intelligence, tics and clumsiness. Developmental Medicine and Child Neurology, 39 691–695.Google Scholar
  40. Nelson, H. E. (1991). National Adult Reading Test (NART): Test manual (rev. ed.). Windsor: NFER-Nelson.Google Scholar
  41. Ross, E. D. (1981). The aprosodies: functional anatomic organization of the affective components of language in the right hemisphere. Archives of Neurology, 38 561–569.Google Scholar
  42. Ross, E. D., & Mesulam, M. M. (1979). Dominant language functions of the right hemisphere? Prosody and emotional gesturing. Archives of Neurology, 36 144–148.Google Scholar
  43. Rourke, B. (1987). Syndrome of non-verbal learning disabilities: the final common pathway of white matter disease/dysfunction? theClinical Neuropsychologist, 1 209–234.Google Scholar
  44. Rourke, B. P. (1988). The syndrome of nonverbal learning disabilities: developmental manifestations in neurological disease, disorder and dysfunction. The Clinical Neuropsychologist, 4, 293–330.Google Scholar
  45. Rourke, B. P. (1989) Noverbal learning disabilities: The syndrome and the model. New York: Guilford Press.Google Scholar
  46. Rourke, B. P. (1995). Syndrome of nonverbal learning disabilities: Neurodevelopmental manifestations. New York: Guilford Press.Google Scholar
  47. Rumsey, J. M. (1992). Neuropsychological studies of high-level autism. In E. Schopler & G. B. Mesibov (Eds.), High-functioning individuals with autism (pp. 41–64). New York: Plenum Press.Google Scholar
  48. Siegal, M., Carrington, J., & Radel, M. (1996). Theory of mind and pragmatic understanding following right-hemisphere brain damage. Brain and Language, 53 40–50.Google Scholar
  49. Sparrow, S., Balla, D., & Cicchetti, D. V. (1984). Vineland Adaptive Scales. Minnesota: American Guidance Service, Circle Pines.Google Scholar
  50. Spreen, O., Strauss, E. (1991). A compendium of neuropsychological tests. New York: Oxford University Press.Google Scholar
  51. Tantam, D. (1988). Annotation: Asperger syndrome. Journal of Child Psychology and Psychiatry, 29 245–255.Google Scholar
  52. Tantam, D. (1991). Asperger syndrome in adulthood. In U. Frith (Ed.), Autism and Asperger syndrome (pp. 147–183). Cambridge: Cambridge University Press.Google Scholar
  53. Tompkins, C. (1995). Right hemisphere communication disorders. San Diego: Singular Publishing.Google Scholar
  54. Tsatsanis, K. D., & Rourke, B. P. (1995). Conclusions and future directions. In B. P. Rourke (Ed.), Syndrome of nonverbal learning disabilities: Neurodevelopmental manifestations ( pp. 476–498). New York: The Guilford Press.Google Scholar
  55. Voeller, K. K. S. (986). Right hemisphere deficit syndrome in children. American Journal of Psychiatry, 143 10004–1009.Google Scholar
  56. Volkmar, F. R., Klin, A., Schultz, R., Bronen, R., Marans, W. D., Sparrow, S., & Cohen, J. (1996). Asperger's syndrome. Journal of American Academy of Child and Adolescent Psychiatry, 35, 118–123.Google Scholar
  57. Warrington, E. K. (Ed.). (1984). Recognition Memory Test Manual. London: NFER-Nelson.Google Scholar
  58. Weintraub, S., & Mesulam, M. M. (1983). Development learning disabilities of the right hemisphere. Archives of Neurology, 40, 464–468.Google Scholar
  59. Winner, E., Brownell, H., Happé, F., Blum, A., Pincus, D. (1998) Distinguishing lies from jokes: theory of mid deficits and discourse interpretation in right-hemisphere brain-damaged patients. Brain and Language, 62 89–106.Google Scholar

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Helen L. Gunter
    • 1
  • Mohammad Ghaziuddin
    • 2
  • Hadyn D. Ellis
    • 1
    Email author
  1. 1.Cardiff UniversitySchool of PsychologyCardiffUK
  2. 2.Medical Center, Child and Adolescent PsychiatryUniversity of MichiganAnn Arbor

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