Advertisement

Pharmaceutical Research

, Volume 2, Issue 5, pp 231–233 | Cite as

Excretion of Metabolites in Bile Following the Administration of Primaquine to Rats

  • John K. Baker
  • James D. McChesney
  • Larry A. Walker
Article

Abstract

Following the administration of primaquine diphosphate (20 mg/kg IP), six metabolites of primaquine were found in the bile of rats. Quantitative HPLC of the metabolites revealed that the sum of the six metabolites excreted in the bile represented a quantitative recovery of the dose of primaquine.

Keywords

HPLC Diphosphate Primaquine Quantitative Recovery Quantitative HPLC 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. (1).
    Clark, A. M., Baker, J. K., McChesney, J. D. (1984) J. Pharm. Sci. 73, 502–506.Google Scholar
  2. (2).
    Baker, J. K., McChesney, J. D., Hufford, C. D., Clark, A. M. (1982) J. Chromatogr. 230, 69–77.Google Scholar
  3. (3).
    Clark, A. M., Hufford, C. D., McChesney, J. D. (1981) Antimicrob. Ag. Chemother. 19, 337–341.Google Scholar
  4. (4).
    Baker, J. K., Bedford, J. A. Clark, A. M., McChesney, J. D. (1984) Pharm. Res. 98–100.Google Scholar
  5. (5).
    Mihaly, G. W., Ward, S. A., Edwards, G., Brechenridge, A. M. (1984) Br. J. Clin. Pharmacol. 17, 441–446.Google Scholar
  6. (6).
    Parkhurst, G. W., Nora, M. V. Thomas, R. W., Carson, P. E. (1984) J. Pharm. Sci. 73, 1329–1331.Google Scholar
  7. (7).
    Nora, M. V., Parkhurst, G. W., Thomas, R. W., Carson, P. E. (1984) J. Chromatogr. 307, 451–456.Google Scholar
  8. (8).
    Mulder, G. J., Scholtens, E., Meijer, D. K. F. (1981) Methods in Enzymology 77, 21–30.Google Scholar
  9. (9).
    Hufford, C. D., Clark, A. M., McChesney, J. D., Baker, J. K. (1984) J. Org. Chem. 49, 2822–2823.Google Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • John K. Baker
    • 1
  • James D. McChesney
    • 2
  • Larry A. Walker
    • 3
  1. 1.Department of Medicinal ChemistryUSA
  2. 2.Department of PharmacognosyUSA
  3. 3.The Research Institute of Pharmaceutical Sciences, School of PharmacyUniversity of Mississippi

Personalised recommendations