Pharmaceutical Research

, Volume 2, Issue 5, pp 231–233 | Cite as

Excretion of Metabolites in Bile Following the Administration of Primaquine to Rats

  • John K. Baker
  • James D. McChesney
  • Larry A. Walker


Following the administration of primaquine diphosphate (20 mg/kg IP), six metabolites of primaquine were found in the bile of rats. Quantitative HPLC of the metabolites revealed that the sum of the six metabolites excreted in the bile represented a quantitative recovery of the dose of primaquine.


HPLC Diphosphate Primaquine Quantitative Recovery Quantitative HPLC 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • John K. Baker
    • 1
  • James D. McChesney
    • 2
  • Larry A. Walker
    • 3
  1. 1.Department of Medicinal ChemistryUSA
  2. 2.Department of PharmacognosyUSA
  3. 3.The Research Institute of Pharmaceutical Sciences, School of PharmacyUniversity of Mississippi

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