Breast Cancer Research and Treatment

, Volume 74, Issue 3, pp 213–220 | Cite as

Prognostic Value of Thermographical Findings in Patients with Primary Breast Cancer

  • Shozo Ohsumi
  • Shigemitsu Takashima
  • Kenjiro Aogi
  • Hisashi Usuki


Thermography is a technique to measure the body surface temperature and is used in medical applications. We evaluated its prognostic value in 340 female patients with unilateral invasive breast cancer without distant metastases. The difference of mean temperatures of the tumor area and corresponding area of the contralateral breast was defined as ΔT. The patients with hot tumors (Δ T ≥ 0.9°C) had significantly worse disease free and specific survival than those with cold tumors (Δ T < 0.9°C) (p = 0.0003 and p < 0.0001, respectively). ΔT was significantly correlated with tumor size, histological nodal status and nuclear grade, positively. But ΔT did not have any relation with estrogen receptor status. Multivariate analyses including those conventional prognostic factors showed that ΔT was a marginally significant prognostic factor for disease-free survival (hazard ratio (HR) = 1.62; 95% confidence interval (CI) = 0.99–2.66, p = 0.0557) and an independent significant prognostic one for disease specific survival (HR = 1.95; 95% CI = 1.09–3.49, p = 0.0251). However, ΔT did not have prognostic impact on the node negative patients. ΔT might be a useful prognostic factor in node positive breast cancer, especially in patients who plan to be treated with preoperative systemic therapy.

breast cancer prognostic factor thermography 


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  1. 1.
    Usuki H, Takashima S, Saeki H, Moriwaki S: Thermographic diagnosis of breast disease. Gan No Rinsho - Jap J Cancer Clinics 32: 958–960, 1986 (in Japanese)Google Scholar
  2. 2.
    Yokoe T, Ishida T, Ogawa T, Iino Y, Kawai T, Izuo M: Role of cancer thermography for detection of breast cancer. Gan No Rinsho - Jap J Cancer Clinics 36: 885–889, 1990 (in Japanese)Google Scholar
  3. 3.
    Bremond A, Ollier V, Drapier-Faure E: Thermography of the breast. Sensitivity, specificity and reproducibility. Bull du Cancer 75(2): 183–186, 1988Google Scholar
  4. 4.
    Ciatto S, Palli D, Rosselli del Turco M, Catarzi S: Diagnostic and prognostic role of infrared thermography. Radiol Medica 74: 312–315, 1987Google Scholar
  5. 5.
    Gros C, Gautherie M, Bourjat P: Prognosis and post-therapeutic follow-up of breast cancers by thermography. Bibliotheca Radiol 6: 77–90, 1975Google Scholar
  6. 6.
    Head JF, Wang F, Elliott RL: Breast thermography is a non-invasive prognostic procedure that predicts tumor growth rate in breast cancer patients. Ann NY Acad Sci 698: 153–158, 1993Google Scholar
  7. 7.
    Ikeda T, Abe O, Enomoto K, Kikuchi K, Fujiwara K: Contact thermography as a prognostic indicator of breast cancer. Gan to Kagaku Ryoho - Jpn J Cancer Chemother 16(5): 2103–2108, 1989 (in Japanese)Google Scholar
  8. 8.
    Isard HJ, Sweitzer CJ, Edelstein GR: Breast thermography. A prognostic indicator for breast cancer survival. Cancer 62: 484–488, 1988Google Scholar
  9. 9.
    Jones CH, Greening WP, Davey JB, McKinna JA, Greeves VJ: Thermography of the female breast: a five-year study in relation to the detection and prognosis of cancer. Br J Radiol 48: 532–538, 1975Google Scholar
  10. 10.
    Mustacchi G, Milani S, Sandri P, De Lazzer F, Ficari F, Monti GF, Adovasio R, Pancrazio F, Pietri P: Telethermography and axillary node status as predictors of early relapse in breast cancer: preliminary report. Tumori 70: 455–458, 1984Google Scholar
  11. 11.
    The Japanese Breast Cancer Society: General rules for clinical and pathological recording of breast cancer. 12th edn, Kinbara Publication Corp, 1996, TokyoGoogle Scholar
  12. 12.
    Tsuda H, Akiyama F, Kurosumi M, Sakamoto G, Watanabe T: Establishment of histological criteria for high-risk node-negative breast carcinoma for a multi-institutional random-ized clinical trial of adjuvant therapy. Jpn J Clin Oncol 28: 486–491, 1998Google Scholar
  13. 13.
    Sterns EE, Zee B, SenGupta S, Saunders FW: Thermography. Its relation to pathologic characteristics, vascularity, proliferation rate, and survival of patients with invasive ductal carcinoma of the breast. Cancer 77: 1324–1328, 1996Google Scholar
  14. 14.
    Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177–182, 1987Google Scholar
  15. 15.
    Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metstasis-correlation in invasive breast carcinoma. N Engl J Med 324: 1–8, 1991Google Scholar
  16. 16.
    Early Breast Cancer Trialists' Collaborative Group: Poly-chemotherapy for early breast cancer: an overview of the randomized trials. Lancet 352: 930–942, 1998Google Scholar
  17. 17.
    Henderson IC, Berry D, Demetri G, Cirrincione C, Goldstein L, Martino S, Ingle JN, Cooper MR, Canellos G, Borden E, Fleming G, Holland JF, Graziano S, Carpenter J, Muss H, Norton L: Improved disease-free (DFS) and overall survival (OS) from the addition of sequential paclitaxel (T) but not from the escalation of doxorubicin (A) dose level in the adjuvant chemotherapy of patients (PTS) with node-positive primary breast cancer (BC). Proc Annu Meet Am Soc Clin Oncol 17: 101a, 1998 (abstr 390A)Google Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Shozo Ohsumi
    • 1
  • Shigemitsu Takashima
    • 1
  • Kenjiro Aogi
    • 1
  • Hisashi Usuki
    • 2
  1. 1.Department of SurgeryNational Shikoku Cancer CenterMatsuyama, Ehime
  2. 2.1st Department of SurgeryKagawa Medical UniversityMiki, KagawaJapan

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