Pharmaceutical Research

, Volume 12, Issue 4, pp 621–629 | Cite as

A Solution Conformation Analysis of Forocidins I and Isoforocidins I Using NMR and Molecular Modeling

  • Kumar Ramu
  • Sachin Shringarpure
  • John S. Williamson
forocidin I isoforocidin I 16-membered macrolides proton-NMR, carbon-NMR, two-dimensional spectra HETCOR COSY modified Karplus equation molecular modeling X-ray demycarosyl leucomycin A3 


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  1. 1.
    R. Corbaz, L. Ettlinger, E. Gaumann, W. Keller-Schierlien, F. Kradolfer, E. Kyburz, L. Neipp, V. Prelog, A. Wettstien and H. Zahner. Stoffwechselprodukte von Actinomyceten. Die Foromacidine A, B, C and D. Helv. Chim. Acta. 39, 304–317 (1956).Google Scholar
  2. 2.
    X. Saez-Lorens. Spiramycin for Treatment of Cryptosporidium Enteritis. J. Infect. Dis. 160, 342 (1989).Google Scholar
  3. 3.
    J. K. A. Beverly, A. P. Freeman, L. Henry and J. P. F. Whelan. Prevention of Pathological Changes in Experimental Congenital Toxoplasma Infections. Lyon Med. 230, 491–495 (1973).Google Scholar
  4. 4.
    K. Ramu, S. Shringarpure, S. Cooperwood, J. M. Beale and J. S. Williamson. 1H-NMR and 13C-NMR Spectral Assignments of Spiramycins I and III. Pharm. Res. 11, 458–465 (1994).Google Scholar
  5. 5.
    M. Hiramatsu, A. Furusaki, T. Noda, K. Naya, Y. Tomiie, I. Nitta, T. Watanabe, T. Take, J. Abe, S. Omura and T. Hata. The Crystal and Molecular Structure of Leucomycin A3 Hydrobromide. Bull. Chem. Soc. 43, 1966–1975 (1970).Google Scholar
  6. 6.
    S. Omura, C. Kitao, H. Hamada and H. Ikeda. Bioconversion and Biosynthesis of 16-Membered Macrolide Antibiotics. X. Final Steps in Biosynthesis of Spiramycin, Using Enzyme Inhibitor: Cerulenin. Chem. Pharm. Bull. 27, 176–182 (1979).Google Scholar
  7. 7.
    O. W. Soerensen, S. Doenstrup, H. Bildsoee and H. J. Jakobsen. Suppression of J Cross-Talk in Subspectral Editing. The SEMUT GL Pulse Sequence. J. Magn. Reson. 55, 347–354 (1983).Google Scholar
  8. 8.
    A. Bax, R. Freeman and G. A. Morris. Correlation of Proton Chemical Shifts by Two-Dimensional Fourier Transform NMR. J. Magn. Reson. 42, 164–168 (1981).Google Scholar
  9. 9.
    A. Bax. Broadband Homonuclear Decoupling in Heteronuclear Shift Correlation NMR Spectroscopy. J. Magn. Reson. 53, 517–520 (1983).Google Scholar
  10. 10.
    W. J. Colucci, S. J. Jungk and R. D. Gandour. An Equation Utilizing Empirically Derived Substituent Constants for the Prediction of Vicinal Coupling Constants in Substituted Ethanes. Magn. Reson. Chem. 23, 335–343 (1985).Google Scholar
  11. 11.
    W. J. Colucci, R. D. Gandour and E. A. Mooberry. Conformational Analysis of Charged Flexible Molecules in Water by Application of a New Karplus Equation Combined with MM2 Computations: Conformations of Carnitine and Acetylcarnitine. J. Am. Chem. Soc. 108, 7141–7147 (1986).Google Scholar
  12. 12.
    H. Sano, M. Inoue, K. Yamashita, R. Okachi and S. Omura. Chemical Modifications of Spiramycins. Synthesis of the Acetal Derivatives of Neospiramycin I. J. Antibiot. 36, 1336–1344 (1983).Google Scholar
  13. 13.
    S. Omura, M. Katagiri, H. Ogura, T. Hata, M. Hiramatsu, T. Kimura, and K. Naya. The Chemistry of Leucomycins. II. Glycosidic Linkages of Mycaminose and Mycarose on Leucomycin A3. Chem. Pharm. Bull. 16, 1402–1404 (1968).Google Scholar

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Kumar Ramu
  • Sachin Shringarpure
  • John S. Williamson

There are no affiliations available

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