Molecular and Cellular Biochemistry

, Volume 234, Issue 1, pp 277–282 | Cite as

Arsenic carcinogenicity: Relevance of c-Src activation

  • Petia P. Simeonova
  • Michael I. Luster
Article

Abstract

Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation.

gene expression reactive oxygen species skin cancer bladder cancer 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Petia P. Simeonova
    • 1
  • Michael I. Luster
    • 1
  1. 1.Toxicology and Molecular Biology Branch, Health Effects Laboratory DivisionNational Institute for Occupational Safety and HealthMorgantowUSA

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