Pharmaceutical Research

, Volume 9, Issue 10, pp 1321–1323 | Cite as

A Quantitative Structure-Activity Relationship (QSAR) Study of Alkylpyrazine Odor Modalities

  • Anna Tsantili-Kakoulidou
  • Lemont B. Kier


The odor strength of a series of alkylpyrazines has been quantitatively investigated applying molecular connectivity, molecular shape, and the recently developed electrotopological state indices. The successful use of the latter parameters indicates that both electronic and topological features contribute to the odor strength of the compounds under study, while the specific role of the two nitrogen atoms is revealed.

alkylpyrazines odor strength molecular connectivity molecular shape electrotopological state index 


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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Anna Tsantili-Kakoulidou
    • 1
  • Lemont B. Kier
    • 2
  1. 1.Division of Pharmaceutical Chemistry, Department of PharmacyUniversity of AthensAthensGreece
  2. 2.Department of Medicinal ChemistryVirginia Commonwealth UniversityRichmond

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