Digestive Diseases and Sciences

, Volume 47, Issue 7, pp 1526–1529 | Cite as

Use of Proton Pump Inhibitors During Pregnancy and Rates of Major Malformations: A Meta-Analysis

  • Shekoufeh Nikfar
  • Mohammad Abdollahi
  • Myla E. Moretti
  • Laura A. Magee
  • Gideon Koren
Article

Abstract

Proton pump inhibitors are used to treat gastroesophageal reflux, a symptom common in pregnancy. The aim of this study was to systematically analyze the available data on the risk for malformations following use of these agents in the first trimester of pregnancy. Medline, EMBASE, published abstracts, and reference lists were searched for articles reporting on proton pump inhibitor use in pregnancy. Summary relative risks and 95% confidence intervals (95% CI) were calculated using the Mantel-Haenszel method. Five cohort studies met the inclusion criteria for this meta-analysis. With almost 600 exposed pregnancies, the overall relative risk was 1.18 with a 95%CI of 0.72–1.94. In conclusion, proton pump inhibitors do not present a major teratogenic risk when used in recommend doses. These data are reassuring for the countless patients who have used these agents in the early part of their pregnancies.

pregnancy drug-induced malformations omeprazole antiulcer agents proton pump inhibitors 

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Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Shekoufeh Nikfar
    • 1
  • Mohammad Abdollahi
    • 2
  • Myla E. Moretti
    • 1
  • Laura A. Magee
    • 1
  • Gideon Koren
    • 1
  1. 1.The Motherisk ProgramHospital for Sick ChildrenTorontoCanada
  2. 2.Faculty of PharmacyUniversity of TorontoCanada

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