Pharmaceutical Research

, Volume 7, Issue 7, pp 756–761 | Cite as

Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women

  • Jennifer B. Dressman
  • Rosemary R. Berardi
  • Lambros C. Dermentzoglou
  • Tanya L. Russell
  • Stephen P. Schmaltz
  • Jeffrey L. Barnett
  • Kathleen M. Jarvenpaa


The pH in the upper gastrointestinal tract of young, healthy men and women was measured in the fasting state and after administration of a standard solid and liquid meal. Calibrated Heidelberg capsules were used to record the pH continuously over the study period of approximately 6 hr. In the fasted state, the median gastric pH was 1.7 and the median duodenal pH was 6.1. When the meal was administered the gastric pH climbed briefly to a median peak value of 6.7, then declined gradually back to the fasted state value over a period of less than 2 hr. In contrast to the pH behavior in the stomach, feeding a meal caused a reduction in the median duodenal pH to 5.4. In addition, there was considerable fluctuation in the postprandial duodenal pH on an intrasubject basis. The pH in the duodenum did not return to fasted state values within the 4-hr postprandial observation period. There was no tendency for the duodenal pH to be related to the gastric pH in either the fed or fasted phases of the study. Furthermore, pH in the upper GI tract of young, healthy subjects appears to be independent of gender. The differences in upper GI pH between the fasted and the fed state are discussed in terms of dosage form performance and absorption for orally administered drugs.

gastric pH duodenal pH fasted state pH fed state pH young adults gender effects carryover pH food effects 


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  1. 1.
    P. Shore, B. Brodie, and A. Hogben. J. Pharmacol. Exp. Ther. 119:361–368 (1957).Google Scholar
  2. 2.
    D. Winne. J. Pharmacokin. Biopharm. 5:53–94 (1977).Google Scholar
  3. 3.
    Med. Lett. 28:41 (1986).Google Scholar
  4. 4.
    H. Ogata, N. Aoyagi, N. Kaniwa, M. Koibuchi, T. Shibazaki, and A. Ejima. Int. J. Clin. Pharmacol. Ther. 20:166–170 (1982).Google Scholar
  5. 5.
    H. Ogata, N. Aoyagi, N. Kaniwa, T. Shibazaki, A. Ejima, Y. Takagishi, T. Ogura, K. Tomita, S. Inoue, and M. Zaizen. Int. J. Pharm. 23:277–288 (1985).Google Scholar
  6. 6.
    J.-R. Malagelada, G. F. Longstreth, W. Summerskill, and V.L. Go. Gastroenterology 70:203–210 (1976).Google Scholar
  7. 7.
    J.-R. Malagelada, V. L. W. Go, T. Deering, W. Summerskill, and V. L. Go. Gastroenterology 73:989–994 (1977).Google Scholar
  8. 8.
    R. McCloy, G. Greenberg, and J. Baron. Gut 25:386–392 (1984).Google Scholar
  9. 9.
    V. Savarino, G. S. Mela, P. Scalabrini, A. Sumbarez, G. Fera, and G. Celle. Digest. Dis. Sci. 9:1077–1080 (1988).Google Scholar
  10. 10.
    D. R. Yarborough, J. C. McIlhany, et al. Am. J. Surg. 117:185–191 (1969).Google Scholar
  11. 11.
    A. V. Aynaciyan and J. R. Bingham. Gastroenterology 56:476–482 (1969).Google Scholar
  12. 12.
    J. M. Williamson, R. I. Russell, and A. Goldberg. Scand. J. Gastro. 4:369–375 (1969).Google Scholar
  13. 13.
    C. A. Youngberg, R. R. Berardi, W. F. Howatt, M. C. Hyneck, G. L. Amidon, J. H. Meyer, and J. B. Dressman. Digest. Dis. Sci. 32:472–480 (1987).Google Scholar
  14. 14.
    G. Dotevall. Acta Med. Scand. 170:59–67 (1961).Google Scholar
  15. 15.
    A. Benn and W. T. Cooke. Scand. J. Gastro. 6:313–317 (1971).Google Scholar
  16. 16.
    H. W. Davenport. A Digest of Digestion, 2nd ed., Yearbook Medical, Chicago, 1978, p. 103.Google Scholar
  17. 17.
    S. Hannibal and S. J. Rune. Eur. J. Clin. Invest. 13:455–460 (1983).Google Scholar
  18. 18.
    L. Ovesen, F. Bendtsen, U. Tage-Jensen, N. T. Pedersen, B. R. Gram, and S. J. Rune. Gastroenterology 90:958–962 (1986).Google Scholar
  19. 19.
    F. Bendtsen, B. Rosenkilde-Gram, U. Tage-Jensen, L. Ovesen, and S. J. Rune. Gastroenterology 93:1263–1269 (1987).Google Scholar
  20. 20.
    H. L. Segal, L. L. Miller, and J. J. Morton. Proc. 5th Natl. GI Cancer Conf., 1953, p. 1079.Google Scholar
  21. 21.
    S. J. Rune and K. Viskum. Gut 10:569–571 (1969).Google Scholar
  22. 22.
    S. J. Rune. In Mageneund Magenkrankheiten, W. Domschke and K. G. Wormsley (eds.) Stuttgart, 1981, p. 150.Google Scholar
  23. 23.
    J. D. Maxwell, A. Ferguson, and W. C. Watson. Digestion 4:345 (1971).Google Scholar
  24. 24.
    P. M. Christiansen. Scand. J. Gastro. 3:497–508 (1968).Google Scholar
  25. 25.
    H. Ogata, N. Aoyagi, N. Kaniwa, A. Ejima, K. Suzuki, T. Ishioka, M. Morishita, K. Ohta, Y. Takagishi, Y. Doi, and T. Ogura. J. Pharm. Dyn. 7:656–664 (1984).Google Scholar
  26. 26.
    R. McGill, J. Tukey, and W. A. Larsen. Am. Stat. 32:12 (1978).Google Scholar
  27. 27.
    P. J. Huber. Robust Statistics, Wiley-Interscience, New York, 1981.Google Scholar
  28. 28.
    C. Chatfield. The Analysis of Time Series—An Introduction, 3rd ed., Chapman and Hall, New York, 1984.Google Scholar
  29. 29.
    Statworks Manual, Cricket Software Inc., Philadelphia, Pa., 1985.Google Scholar
  30. 30.
    J. L. Devore. Probability and Statistics for Engineering and the Sciences, Brooks/Cole, Monterey, Calif., 1982.Google Scholar
  31. 31.
    Statview II Manual, Abacus Concepts, BrainPower, Inc., Calabasas, Calif., 1988.Google Scholar

Copyright information

© Plenum Publishing Corporation 1990

Authors and Affiliations

  • Jennifer B. Dressman
    • 1
  • Rosemary R. Berardi
    • 1
  • Lambros C. Dermentzoglou
    • 1
  • Tanya L. Russell
    • 1
  • Stephen P. Schmaltz
    • 2
  • Jeffrey L. Barnett
    • 3
  • Kathleen M. Jarvenpaa
    • 1
  1. 1.College of PharmacyUniversity of MichiganAnn Arbor
  2. 2.Clinical Research CenterUniversity of MichiganAnn Arbor
  3. 3.Department of Internal MedicineUniversity of MichiganAnn Arbor

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