Breast-feeding and neuroblastoma, USA and Canada
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- Daniels, J.L., Olshan, A.F., Pollock, B.H. et al. Cancer Causes Control (2002) 13: 401. doi:10.1023/A:1015746701922
Objective: Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case–control study in the United States and Canada. Methods: Maternal reports of breast-feeding were compared among 393 children six months or older who had neuroblastoma and were identified through the Children's Cancer Group and the Pediatric Oncology Group and 376 age-matched controls identified by random-digit telephone dialing in a telephone interview case–control study. Results: Children with neuroblastoma were less likely to have breast-fed than control children (odds ratio (OR) = 0.6; 95% confidence interval (CI) = 0.5–0.9). The association between breast-feeding and neuroblastoma increased with breast-feeding duration (0–3 months OR = 0.7, CI = 0.4–1.0; 13+ months OR = 0.5, CI = 0.3–0.9). Conclusion: Breast-feeding was inversely associated with neuroblastoma and should be encouraged among healthy mothers. Additional research on possible mechanisms of this association may be warranted.
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