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Russian Journal of Bioorganic Chemistry

, Volume 28, Issue 3, pp 257–261 | Cite as

Synthesis of 24-Functionalized Oxysterols

  • V. A. Khripach
  • V. N. Zhabinskii
  • O. V. Konstantinova
  • N. B. Khripach
  • A. P. Antonchick
Article

Abstract

The syntheses of (24S)-24,25-epoxycholesterol, (24S)-hydroxycholesterol, and 24-ketocholesterol are described. The compounds belong to oxysterols, which can be considered to be the modulators of cholesterol metabolism. The asymmetric hydroxylation of desmosterol acetate according to Sharpless was used as the key reaction in the stereoselective introduction of functionality in position 24.

asymmetric hydroxylation cholesterol oxysterols steroids 

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Copyright information

© MAIK “Nauka/Interperiodica” 2002

Authors and Affiliations

  • V. A. Khripach
    • 1
  • V. N. Zhabinskii
    • 1
  • O. V. Konstantinova
    • 1
  • N. B. Khripach
    • 1
  • A. P. Antonchick
    • 1
  1. 1.National Academy of Sciences of BelarusInstitute of Bioorganic ChemistryMinskBelarus

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