Pharmacy World and Science

, Volume 24, Issue 2, pp 67–70 | Cite as

Intravenous to oral conversion of fluoroquinolones: knowledge versus clinical practice patterns

  • Ornella Conort
  • Marie-Pauline Fitzpatrick
  • Georges Hazebroucq
  • Alain Cariou
  • Steven Gabardi


Study Objectives: To assess the knowledge of prescribers regarding intravenous to oral conversions of fluoroquinolones, the frequency and time until conversion, and to compare prescriber knowledge with the data collected concerning the reasons stated for continuation of intravenous fluoroquinolones.Design: Prospective chart review and questionnaire.Setting: Large teaching hospital in Paris, France.Patients: Fifty-one males and females.Intervention: data were collected on in-patients receiving intravenous fluoroquinolone for at least three days and hospitalized in one of six in-patient units. Patients receiving intravenous fluoroquinolone for less than three days were excluded. A questionnaire to assess the awareness of a potential conversion was distributed to those practitioners who had patients reviewed during the data-collection phase.Main Results: the questionnaire revealed the ten most common reasons for continuing intravenous administration for more than three days. However, the physicians agreed that most patients should be converted as soon as possible. Practice patterns differed, with only 17 of 51 patients actually converted to oral therapy.Conclusion: in theory, the clinicians were aware of when to perform the conversion. However, in practice, the frequency of conversion was lower than optimum. Changes in clinical practice are needed to decrease the costs of intravenous therapy, without jeopardizing quality of care.

Chart review Fluoroquinolones France Knowledge Oral administration Parental administration Practice patterns 


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  1. 1.
    Chrysanthopoulos C.J., Starakis J.C., Skoutelis A.T. et al. Brief report: sequential intravenous/oral therapy with ciprofloxacin in severe infection. Am J Med 1989;87(suppl 5A):225-7.Google Scholar
  2. 2.
    Gangji D, Jacobs F., De Jonckheer J. et al-Brief report: randomized study of intravenous versus sequential intravenous/oral regimen of ciprofloxacin in the treatment of gram-negative septicemia. Am J Med 1989;87(suppl 5A):206-8.Google Scholar
  3. 3.
    Regamey C., Steinbach-Lebbin C. Severe infections treated with intravenous ofloxacin: a prospective clinical multicentre Swiss study. J Antimicrob Chemother 1990;26(suppl.D):107-14.Google Scholar
  4. 4.
    Trenholme G.M, Schmitt B.A., Spear J. et al. Randomized study of intravenous/oral ciprofloxacin versus ceftazidime in the treatment of hospital and nursing home patients with lower respiratory tract infections. Am J Med 1989;87(suppl 5A):116-8.Google Scholar
  5. 5.
    Amodio-Groton M., Madu A., Madu al. Sequential parenteral and oral ciprofloxacin regimen versus parenteral therapy for bacteremia: a pharmacoeconomic analysis. Ann Pharmacotherapy 1996;30:596-602.Google Scholar
  6. 6.
    Balfour J.A., Faulds D. Oral ciprofloxacin: a pharmacoeconomic evaluation of its use in the treatment of serious infections. Pharmacoeconomics 1993;3(5):398-421.Google Scholar
  7. 7.
    Fligelman R.M., Mattingly P.M., Dempsey C.L et al. Economic impact of oral ciprofloxacin following standard intravenous therapy. Diagn Microbiol Infect Dis 1990;13:187-9.Google Scholar
  8. 8.
    Paladino J.A., Sperry H.E., Backes J.M et al. Clinical and economic evaluation of oral ciprofloxacin after an abbreviated course of intravenous antibiotics. Am J Med 1991;91:462-70.Google Scholar
  9. 9.
    Ramirez JA, Vargas S, Ritter GW, et al. Early Switch From Intravenous to Oral Antibiotics and Early Hospital Discharge. Arch Intern Med 1999;159:2449-54.Google Scholar
  10. 10.
    Mandell LA, Bergeron MG, Gribble MJ, et al. Sequential antibiotics therapy: effective cost management and patient care. Can J Infect Dis 1995;6;306-15.Google Scholar
  11. 11.
    Przybylski KG, Rybak MJ, Matin PR, et al. A pharmacist-initiated program of intravenous to oral antibiotic conversion. Pharmacotherapy 1997;17(2);271-6.Google Scholar
  12. 12.
    Sevinç F, Prins JM, Koopmans RP, et al. Early switch from intravenous to oral antibiotics: guidelines and implementation in a large teaching hospital. J Antimicrob Chemother 1999;43;601-6.Google Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Ornella Conort
    • 1
  • Marie-Pauline Fitzpatrick
    • 1
  • Georges Hazebroucq
    • 1
  • Alain Cariou
    • 2
  • Steven Gabardi
    • 3
    • 4
  1. 1.Department of PharmacyCochin HospitalParisFrance
  2. 2.Department of MedicineUSA
  3. 3.Department of Pharmacy ServicesBrigham and Women's HospitalUSA
  4. 4.Department of Clinical Pharmacy PracticeNortheastern UniversityBostonUSA

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