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Virus Genes

, Volume 24, Issue 3, pp 275–290 | Cite as

Papillomavirus E1 Proteins: Form, Function, and Features

  • Van G. WilsonEmail author
  • Michael West
  • Kelly Woytek
  • Dandapani Rangasamy
Article

Abstract

The E1 proteins are the essential origin recognition proteins for papillomavirus (PV) replication. E1 proteins bind to specific DNA elements in the viral origin of replication and assemble into hexameric helicases with the aid of a second viral protein, E2. The resultant helicase complex initiates origin DNA unwinding to provide the template for subsequent syntheses of progeny DNA. In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase α and RPA. This review will compare the basic structures and features of the human (HPV) and bovine (BPV1) papillomaviruses with an emphasis on mechanisms of replication function.

DNA binding proteins DNA replication helicase papovavirus 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Van G. Wilson
    • 1
    Email author
  • Michael West
    • 1
  • Kelly Woytek
    • 1
  • Dandapani Rangasamy
    • 1
  1. 1.Department of Medical Microbiology and Immunology, College of MedicineTexas A&M University System Health Science CenterCollege StationUSA

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