Archives of Sexual Behavior

, Volume 31, Issue 3, pp 289–293 | Cite as

Does Semen Have Antidepressant Properties?

  • Gordon G. Jr. Gallup
  • Rebecca L. Burch
  • Steven M. Platek


In a sample of sexually active college females, condom use, as an indirect measure of the presence of semen in the reproductive tract, was related to scores on the Beck Depression Inventory. Not only were females who were having sex without condoms less depressed, but depressive symptoms and suicide attempts among females who used condoms were proportional to the consistency of condom use. For females who did not use condoms, depression scores went up as the amount of time since their last sexual encounter increased. These data are consistent with the possibility that semen may antagonize depressive symptoms and evidence which shows that the vagina absorbs a number of components of semen that can be detected in the bloodstream within a few hours of administration.

semen depressive symptoms vaginal absorption condom use sexual activity 


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  1. Abdullah, Y. H., & Hamadah, K. (1975). Effect of ADP on PGE1 formation in the blood platelets from patients with depression, mania and schizophrenia. British Journal of Psychiatry, 127, 591–595.Google Scholar
  2. Beck, A. T. (1961). A systematic investigation of depression. Comprehensive Psychiatry, 2, 163–170.PubMedGoogle Scholar
  3. Benziger, D. P., & Edelson, J. (1983). Absorption from the vagina. Drug Metabolism Reviews, 14, 137–168.PubMedGoogle Scholar
  4. Coope, J. (1996). Hormonal and non-hormonal interventions for menopausal symptoms. Maturitas, 23, 159–168.PubMedGoogle Scholar
  5. Culbertson, F. M. (1997). Depression and gender: An international review. American Psychologist, 52, 25–31.PubMedGoogle Scholar
  6. Dilley, J. W., McFarland, W., Sullivan, P., & Discepola, M. (1998). Psychosocial correlates of unprotected anal sex in a cohort of gay men attending an HIV-negative support group. AIDS Education and Prevention, 10, 317–326.PubMedGoogle Scholar
  7. Eliasson, R., & Posse, N. (1965). Rubin's test before and after intravaginal application of prostaglandin. International Journal of Fertility, 10, 373.PubMedGoogle Scholar
  8. Keller, P. J., Riedmann, R., Fischer, M., & Gerber, C. (1981). Oestrogens, gonadotropins and prolactin after intra-vaginal administration of oestriol in post-menopausal women. Maturitas, 3, 47–53.PubMedGoogle Scholar
  9. McCusker, J., Goldstein, R. B., Bigelow, C., & Zorn, M. (1995). Psychiatric status and HIV risk reduction among residential drug abuse treatment clients. Addiction, 90, 1377–1387.PubMedGoogle Scholar
  10. Ney, P. G. (1986). The intravaginal absorption of male generated hormones and their possible effect on female behavior. Medical Hypotheses, 20, 221–231.PubMedGoogle Scholar
  11. Rigg, L. A., Milanes, B., Villanueva, B., & Yen, S. C. C. (1977). Efficacy of intravaginal and intranasal administration of micronized estradiol 17-beta. Journal of Clinical Endocrinology and Metabolism, 45, 1261–1264.PubMedGoogle Scholar
  12. Roy-Byrne, P. P., Rubinow, D. R., Gold, P. W., & Post, R. M. (1984). Possible antidepressant effects of oral contraceptives: Case report. Journal of Clinical Psychiatry, 45, 350–352.PubMedGoogle Scholar
  13. Sandberg, F., Ingelman-Sundberg, A., Ryden, G., & Joelsson, I. (1968). The absorption of tritium labeled prostaglandin E1 from the vagina of non-pregnant women. Acta Obstetricia et Gynecologica Scandinavica, 47, 22–26.PubMedGoogle Scholar
  14. Schiff, I., Tulchinsky, D., & Ryan, K. J. (1977). Vaginal absorption of estrone and 17-beta estradiol. Fertility and Sterility, 28, 1063–1066.PubMedGoogle Scholar
  15. Shanfield, S. B., & Swain, B. J. (1984). Death of adult children in traffic accidents. Journal of Nervous and Mental Disease, 172, 533–538.PubMedGoogle Scholar
  16. Suarez, S. D., & Gallup, G. G., Jr. (1985). Depression as a response to reproductive failure. Journal of Social and Biological Structures, 8, 279–287.Google Scholar
  17. Thomas, V., & Striegel, P. (1994). Stress and grief of a perinatal loss: Integrating qualitative and quantitative methods. Omega: Journal of Death and Dying, 30, 299–311.Google Scholar
  18. Vance, J. C., Boyle, F. M., Najman, J. M., & Thearle, M. J. (1995). Gender differences in parental psychological distress following perinatal death or sudden infant death syndrome. British Journal of Psychiatry, 167, 806–811.Google Scholar
  19. Wester, R. C., Noonan, P. K., & Maibach, H. I. (1980). Variations in percutaneous absorption of testosterone in the rhesus monkey due to anatomic site of application and frequency of application. Archives of Dermatological Research, 267, 229–235.PubMedGoogle Scholar
  20. Winter, L. B., Steer, R. A., Jones-Hicks, L., & Beck, A. T. (1999). Screening for depressive disorders in adolescent medical outpatients with the Beck depression inventory for primary care. Journal of Adolescent Health, 24, 389–394.CrossRefPubMedGoogle Scholar
  21. Yamazaki, I. (1984). Serum concentration patterns of an LHRH agonist, gonadotrophins and sex steroids after subcutaneous, vaginal, rectal and nasal administration of the agonist to pregnant rats. Journal of Reproduction and Fertility, 72, 129–136.PubMedGoogle Scholar
  22. Zweifel, J. E., & O'Brien, W. H. (1997). A meta-analysis of the effect of hormone replacement therapy upon depressed mood. Psychoneuroendocrinology, 22, 189–212.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Gordon G. Jr. Gallup
    • 1
  • Rebecca L. Burch
    • 1
  • Steven M. Platek
    • 1
  1. 1.Department of PsychologyState University of New York at AlbanyAlbany

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